---
_id: '877'
abstract:
- lang: eng
  text: "Sequence analysis of protein and mitochondrially encoded tRNA genes shows
    that substitutions\r\nproducing pathogenic effects in humans are often found in
    normal, healthy individuals from other species.\r\nAnalysis of stability of protein
    and tRNA structures shows that the disease-causing effects of pathogenic\r\nmutations
    can be neutralized by other, compensatory substitutions that restore the structural
    stability of the\r\nmolecule. Further study of such substitutions will, hopefully,
    lead to new methods for curing genetic dis-\r\neases that may be based on the
    correction of molecule stability as a whole instead of reversing an individual\r\npathogenic
    mutation."
article_processing_charge: No
article_type: original
author:
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
citation:
  ama: Kondrashov F. The analysis of monomer sequences in protein and tRNA and the
    manifestation of the compensation of pathogenic deviations in their evolution.
    <i>Biofizika</i>. 2005;50(3):389-395.
  apa: Kondrashov, F. (2005). The analysis of monomer sequences in protein and tRNA
    and the manifestation of the compensation of pathogenic deviations in their evolution.
    <i>Biofizika</i>. Pleiades Publishing.
  chicago: Kondrashov, Fyodor. “The Analysis of Monomer Sequences in Protein and TRNA
    and the Manifestation of the Compensation of Pathogenic Deviations in Their Evolution.”
    <i>Biofizika</i>. Pleiades Publishing, 2005.
  ieee: F. Kondrashov, “The analysis of monomer sequences in protein and tRNA and
    the manifestation of the compensation of pathogenic deviations in their evolution,”
    <i>Biofizika</i>, vol. 50, no. 3. Pleiades Publishing, pp. 389–395, 2005.
  ista: Kondrashov F. 2005. The analysis of monomer sequences in protein and tRNA
    and the manifestation of the compensation of pathogenic deviations in their evolution.
    Biofizika. 50(3), 389–395.
  mla: Kondrashov, Fyodor. “The Analysis of Monomer Sequences in Protein and TRNA
    and the Manifestation of the Compensation of Pathogenic Deviations in Their Evolution.”
    <i>Biofizika</i>, vol. 50, no. 3, Pleiades Publishing, 2005, pp. 389–95.
  short: F. Kondrashov, Biofizika 50 (2005) 389–395.
date_created: 2018-12-11T11:48:58Z
date_published: 2005-05-01T00:00:00Z
date_updated: 2021-01-12T08:21:01Z
day: '01'
extern: '1'
external_id:
  pmid:
  - '15977826'
intvolume: '        50'
issue: '3'
language:
- iso: eng
main_file_link:
- url: http://pleiades.online/abstract/biophys/5/biophys0349_abstract.pdf
month: '05'
oa_version: None
page: 389 - 395
pmid: 1
publication: Biofizika
publication_status: published
publisher: Pleiades Publishing
publist_id: '6769'
quality_controlled: '1'
status: public
title: The analysis of monomer sequences in protein and tRNA and the manifestation
  of the compensation of pathogenic deviations in their evolution
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 50
year: '2005'
...