article published Fyodor Kondrashov author 44FDEF62-F248-11E8-B48F-1D18A9856A870000-0001-8243-4694 Negative trade-offs are thought to be a pervasive phenomenon and to inhibit evolution at all levels. New evidence shows that at the molecular level, there may be no trade-offs preventing the emergence of an enzyme with multiple functions. Nature Publishing Group2005 10.1038/ng0105-9 3719 - 10 yes F. Kondrashov, Nature Genetics 37 (2005) 9–10. Kondrashov, F. (2005). In search of the limits of evolution. <i>Nature Genetics</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/ng0105-9">https://doi.org/10.1038/ng0105-9</a> F. Kondrashov, “In search of the limits of evolution,” <i>Nature Genetics</i>, vol. 37, no. 1. Nature Publishing Group, pp. 9–10, 2005. Kondrashov F. 2005. In search of the limits of evolution. Nature Genetics. 37(1), 9–10. Kondrashov, Fyodor. “In Search of the Limits of Evolution.” <i>Nature Genetics</i>. Nature Publishing Group, 2005. <a href="https://doi.org/10.1038/ng0105-9">https://doi.org/10.1038/ng0105-9</a>. Kondrashov F. In search of the limits of evolution. <i>Nature Genetics</i>. 2005;37(1):9-10. doi:<a href="https://doi.org/10.1038/ng0105-9">10.1038/ng0105-9</a> Kondrashov, Fyodor. “In Search of the Limits of Evolution.” <i>Nature Genetics</i>, vol. 37, no. 1, Nature Publishing Group, 2005, pp. 9–10, doi:<a href="https://doi.org/10.1038/ng0105-9">10.1038/ng0105-9</a>. 8782018-12-11T11:48:59Z2021-01-12T08:21:02Z