article published Fyodor Kondrashov author 44FDEF62-F248-11E8-B48F-1D18A9856A870000-0001-8243-4694 Tatiana Gurbich author Peter Vlasov author Having an extra copy of a gene is thought to provide some functional redundancy, which results in a higher rate of evolution in duplicated genes. In this article, we estimate the impact of gene duplication on the selection of tuf paralogs, and we find that in the absence of gene conversion, tuf paralogs have evolved significantly slower than when gene conversion has been a factor in their evolution. Thus, tuf gene copies evolve under a selective pressure that ensures their functional uniformity, and gene conversion reduces selection against amino acid substitutions that affect the function of the encoded protein, EF-Tu. Elsevier2007 10.1016/j.tig.2007.03.002 235215 - 218 yes Kondrashov F, Gurbich T, Vlasov P. 2007. Selection for functional uniformity of tuf duplicates in γ-proteobacteria. Trends in Genetics. 23(5), 215–218. Kondrashov, Fyodor, Tatiana Gurbich, and Peter Vlasov. “Selection for Functional Uniformity of Tuf Duplicates in γ-Proteobacteria.” <i>Trends in Genetics</i>. Elsevier, 2007. <a href="https://doi.org/10.1016/j.tig.2007.03.002">https://doi.org/10.1016/j.tig.2007.03.002</a>. Kondrashov, F., Gurbich, T., &#38; Vlasov, P. (2007). Selection for functional uniformity of tuf duplicates in γ-proteobacteria. <i>Trends in Genetics</i>. Elsevier. <a href="https://doi.org/10.1016/j.tig.2007.03.002">https://doi.org/10.1016/j.tig.2007.03.002</a> F. Kondrashov, T. Gurbich, P. Vlasov, Trends in Genetics 23 (2007) 215–218. F. Kondrashov, T. Gurbich, and P. Vlasov, “Selection for functional uniformity of tuf duplicates in γ-proteobacteria,” <i>Trends in Genetics</i>, vol. 23, no. 5. Elsevier, pp. 215–218, 2007. Kondrashov F, Gurbich T, Vlasov P. Selection for functional uniformity of tuf duplicates in γ-proteobacteria. <i>Trends in Genetics</i>. 2007;23(5):215-218. doi:<a href="https://doi.org/10.1016/j.tig.2007.03.002">10.1016/j.tig.2007.03.002</a> Kondrashov, Fyodor, et al. “Selection for Functional Uniformity of Tuf Duplicates in γ-Proteobacteria.” <i>Trends in Genetics</i>, vol. 23, no. 5, Elsevier, 2007, pp. 215–18, doi:<a href="https://doi.org/10.1016/j.tig.2007.03.002">10.1016/j.tig.2007.03.002</a>. 8792018-12-11T11:48:59Z2021-01-12T08:21:04Z