--- res: bibo_abstract: - Multicellular eukaryotes have evolved a range of mechanisms for immune recognition. A widespread family involved in innate immunity are the NACHT-domain and leucine-rich-repeat-containing (NLR) proteins.Mammals have small numbers of NLR proteins, whereas in some species, mostly those without adaptive immune systems, NLRs have expanded into very large families.We describe a family of nearly 400NLR proteins encoded in the zebrafish genome. The proteins share a defining overall structure, which arose in fishes after a fusion of the core NLR domains with a B30.2 domain, but can be subdivided into four groups based on their NACHT domains. Gene conversion acting differentially on the NACHT and B30.2 domains has shaped the family and created the groups. Evidence of positive selection in the B30.2 domain indicates that this domain rather than the leucine-rich repeats acts as the pathogen recognition module. In an unusual chromosomal organization, the majority of the genes are located on one chromosome arm, interspersed with other large multigene families, including a new family encoding zinc-finger proteins. The NLR-B30.2 proteins represent a new family with diversity in the specific recognition module that is present in fishes in spite of the parallel existence of an adaptive immune system.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Kerstin foaf_name: Howe, Kerstin L foaf_surname: Howe - foaf_Person: foaf_givenName: Philipp foaf_name: Schiffer, Philipp H foaf_surname: Schiffer - foaf_Person: foaf_givenName: Julia foaf_name: Zielinski, Julia G foaf_surname: Zielinski - foaf_Person: foaf_givenName: Thomas foaf_name: Wiehe, Thomas H foaf_surname: Wiehe - foaf_Person: foaf_givenName: Gavin foaf_name: Laird, Gavin K foaf_surname: Laird - foaf_Person: foaf_givenName: John foaf_name: Marioni, John C foaf_surname: Marioni - foaf_Person: foaf_givenName: Onuralp foaf_name: Soylemez, Onuralp foaf_surname: Soylemez - foaf_Person: foaf_givenName: Fyodor foaf_name: Fyodor Kondrashov foaf_surname: Kondrashov foaf_workInfoHomepage: http://www.librecat.org/personId=44FDEF62-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-8243-4694 - foaf_Person: foaf_givenName: Maria foaf_name: Leptin, Maria foaf_surname: Leptin bibo_doi: 10.1098/rsob.160009 bibo_issue: '4' bibo_volume: 6 dct_date: 2016^xs_gYear dct_publisher: Royal Society, The@ dct_title: Structure and evolutionary history of a large family of NLR proteins in the zebrafish@ ...