---
res:
  bibo_abstract:
  - During development, a single cell is transformed into a highly complex organism
    through progressive cell division, specification and rearrangement. An important
    prerequisite for the emergence of patterns within the developing organism is to
    establish asymmetries at various scales, ranging from individual cells to the
    entire embryo, eventually giving rise to the different body structures. This becomes
    especially apparent during gastrulation, when the earliest major lineage restriction
    events lead to the formation of the different germ layers. Traditionally, the
    unfolding of the developmental program from symmetry breaking to germ layer formation
    has been studied by dissecting the contributions of different signaling pathways
    and cellular rearrangements in the in vivo context of intact embryos. Recent efforts,
    using the intrinsic capacity of embryonic stem cells to self-assemble and generate
    embryo-like structures de novo, have opened new avenues for understanding the
    many ways by which an embryo can be built and the influence of extrinsic factors
    therein. Here, we discuss and compare divergent and conserved strategies leading
    to germ layer formation in embryos as compared to in vitro systems, their upstream
    molecular cascades and the role of extrinsic factors in this process.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Alexandra
      foaf_name: Schauer, Alexandra
      foaf_surname: Schauer
      foaf_workInfoHomepage: http://www.librecat.org/personId=30A536BA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-7659-9142
  - foaf_Person:
      foaf_givenName: Carl-Philipp J
      foaf_name: Heisenberg, Carl-Philipp J
      foaf_surname: Heisenberg
      foaf_workInfoHomepage: http://www.librecat.org/personId=39427864-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-0912-4566
  bibo_doi: 10.1016/j.ydbio.2020.12.014
  bibo_volume: 474
  dct_date: 2021^xs_gYear
  dct_identifier:
  - UT:000639461800008
  dct_isPartOf:
  - http://id.crossref.org/issn/0012-1606
  dct_language: eng
  dct_publisher: Elsevier@
  dct_subject:
  - Developmental Biology
  - Cell Biology
  - Molecular Biology
  dct_title: Reassembling gastrulation@
  fabio_hasPubmedId: '33352181'
...