--- res: bibo_abstract: - Metabolic adaptation is a critical feature of migrating cells. It tunes the metabolic programs of migrating cells to allow them to efficiently exert their crucial roles in development, inflammatory responses and tumor metastasis. Cell migration through physically challenging contexts requires energy. However, how the metabolic reprogramming that underlies in vivo cell invasion is controlled is still unanswered. In my PhD project, I identify a novel conserved metabolic shift in Drosophila melanogaster immune cells that by modulating their bioenergetic potential controls developmentally programmed tissue invasion. We show that this regulation requires a novel conserved nuclear protein, named Atossa. Atossa enhances the transcription of a set of proteins, including an RNA helicase Porthos and two metabolic enzymes, each of which increases the tissue invasion of leading Drosophila macrophages and can rescue the atossa mutant phenotype. Porthos selectively regulates the translational efficiency of a subset of mRNAs containing a 5’-UTR cis-regulatory TOP-like sequence. These 5’TOPL mRNA targets encode mitochondrial-related proteins, including subunits of mitochondrial oxidative phosphorylation (OXPHOS) components III and V and other metabolic-related proteins. Porthos powers up mitochondrial OXPHOS to engender a sufficient ATP supply, which is required for tissue invasion of leading macrophages. Atossa’s two vertebrate orthologs rescue the invasion defect. In my PhD project, I elucidate that Atossa displays a conserved developmental metabolic control to modulate metabolic capacities and the cellular energy state, through altered transcription and translation, to aid the tissue infiltration of leading cells into energy demanding barriers.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Shamsi foaf_name: Emtenani, Shamsi foaf_surname: Emtenani foaf_workInfoHomepage: http://www.librecat.org/personId=49D32318-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-6981-6938 bibo_doi: 10.15479/AT:ISTA:8983 dct_date: 2020^xs_gYear dct_isPartOf: - http://id.crossref.org/issn/2663-337X dct_language: eng dct_publisher: Institute of Science and Technology Austria@ dct_title: Metabolic regulation of Drosophila macrophage tissue invasion@ ...