---
res:
  bibo_abstract:
  - The differentiation of cells depends on a precise control of their internal organization,
    which is the result of a complex dynamic interplay between the cytoskeleton, molecular
    motors, signaling molecules, and membranes. For example, in the developing neuron,
    the protein ADAP1 (ADP-ribosylation factor GTPase-activating protein [ArfGAP]
    with dual pleckstrin homology [PH] domains 1) has been suggested to control dendrite
    branching by regulating the small GTPase ARF6. Together with the motor protein
    KIF13B, ADAP1 is also thought to mediate delivery of the second messenger phosphatidylinositol
    (3,4,5)-trisphosphate (PIP3) to the axon tip, thus contributing to PIP3 polarity.
    However, what defines the function of ADAP1 and how its different roles are coordinated
    are still not clear. Here, we studied ADAP1’s functions using in vitro reconstitutions.
    We found that KIF13B transports ADAP1 along microtubules, but that PIP3 as well
    as PI(3,4)P2 act as stop signals for this transport instead of being transported.
    We also demonstrate that these phosphoinositides activate ADAP1’s enzymatic activity
    to catalyze GTP hydrolysis by ARF6. Together, our results support a model for
    the cellular function of ADAP1, where KIF13B transports ADAP1 until it encounters
    high PIP3/PI(3,4)P2 concentrations in the plasma membrane. Here, ADAP1 disassociates
    from the motor to inactivate ARF6, promoting dendrite branching.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Christian F
      foaf_name: Düllberg, Christian F
      foaf_surname: Düllberg
      foaf_workInfoHomepage: http://www.librecat.org/personId=459064DC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6335-9748
  - foaf_Person:
      foaf_givenName: Albert
      foaf_name: Auer, Albert
      foaf_surname: Auer
      foaf_workInfoHomepage: http://www.librecat.org/personId=3018E8C2-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-3580-2906
  - foaf_Person:
      foaf_givenName: Nikola
      foaf_name: Canigova, Nikola
      foaf_surname: Canigova
      foaf_workInfoHomepage: http://www.librecat.org/personId=3795523E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8518-5926
  - foaf_Person:
      foaf_givenName: Katrin
      foaf_name: Loibl, Katrin
      foaf_surname: Loibl
      foaf_workInfoHomepage: http://www.librecat.org/personId=3760F32C-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-2429-7668
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Loose, Martin
      foaf_surname: Loose
      foaf_workInfoHomepage: http://www.librecat.org/personId=462D4284-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-7309-9724
  bibo_doi: 10.1073/pnas.2010054118
  bibo_issue: '1'
  bibo_volume: 118
  dct_date: 2021^xs_gYear
  dct_identifier:
  - UT:000607270100018
  dct_isPartOf:
  - http://id.crossref.org/issn/0027-8424
  - http://id.crossref.org/issn/1091-6490
  dct_language: eng
  dct_publisher: National Academy of Sciences@
  dct_title: In vitro reconstitution reveals phosphoinositides as cargo-release factors
    and activators of the ARF6 GAP ADAP1@
  fabio_hasPubmedId: '33443153'
...