article published yes Shutang Tan author 2DE75584-F248-11E8-B48F-1D18A9856A870000-0002-0471-8285 Christian Luschnig author Jiří Friml author 4159519E-F248-11E8-B48F-1D18A9856A870000-0002-8302-7596 JiFr department Tracing Evolution of Auxin Transport and Polarity in Plants project Molecular Mechanism underlying Salicylic Acid Regulation of Endocytic Trafficking in Arabidopsis project The phytohormone auxin plays a central role in shaping plant growth and development. With decades of genetic and biochemical studies, numerous core molecular components and their networks, underlying auxin biosynthesis, transport, and signaling, have been identified. Notably, protein phosphorylation, catalyzed by kinases and oppositely hydrolyzed by phosphatases, has been emerging to be a crucial type of post-translational modification, regulating physiological and developmental auxin output at all levels. In this review, we comprehensively discuss earlier and recent advances in our understanding of genetics, biochemistry, and cell biology of the kinases and phosphatases participating in auxin action. We provide insights into the mechanisms by which reversible protein phosphorylation defines developmental auxin responses, discuss current challenges, and provide our perspectives on future directions involving the integration of the control of protein phosphorylation into the molecular auxin network. https://research-explorer.ista.ac.at/download/8992/8995/2020_MolecularPlant_Tan.pdf application/pdfno Elsevier2021 eng 1674-2052 1752-9867 33186755 00060535940001410.1016/j.molp.2020.11.004 141151-165 Tan S, Luschnig C, Friml J. 2021. Pho-view of auxin: Reversible protein phosphorylation in auxin biosynthesis, transport and signaling. Molecular Plant. 14(1), 151–165. Tan, S., Luschnig, C., &#38; Friml, J. (2021). Pho-view of auxin: Reversible protein phosphorylation in auxin biosynthesis, transport and signaling. <i>Molecular Plant</i>. Elsevier. <a href="https://doi.org/10.1016/j.molp.2020.11.004">https://doi.org/10.1016/j.molp.2020.11.004</a> S. Tan, C. Luschnig, and J. Friml, “Pho-view of auxin: Reversible protein phosphorylation in auxin biosynthesis, transport and signaling,” <i>Molecular Plant</i>, vol. 14, no. 1. Elsevier, pp. 151–165, 2021. Tan, Shutang, Christian Luschnig, and Jiří Friml. “Pho-View of Auxin: Reversible Protein Phosphorylation in Auxin Biosynthesis, Transport and Signaling.” <i>Molecular Plant</i>. Elsevier, 2021. <a href="https://doi.org/10.1016/j.molp.2020.11.004">https://doi.org/10.1016/j.molp.2020.11.004</a>. Tan S, Luschnig C, Friml J. Pho-view of auxin: Reversible protein phosphorylation in auxin biosynthesis, transport and signaling. <i>Molecular Plant</i>. 2021;14(1):151-165. doi:<a href="https://doi.org/10.1016/j.molp.2020.11.004">10.1016/j.molp.2020.11.004</a> S. Tan, C. Luschnig, J. Friml, Molecular Plant 14 (2021) 151–165. Tan, Shutang, et al. “Pho-View of Auxin: Reversible Protein Phosphorylation in Auxin Biosynthesis, Transport and Signaling.” <i>Molecular Plant</i>, vol. 14, no. 1, Elsevier, 2021, pp. 151–65, doi:<a href="https://doi.org/10.1016/j.molp.2020.11.004">10.1016/j.molp.2020.11.004</a>. 89922021-01-03T23:01:23Z2025-07-10T12:01:28Z