The logic of developing neocortical circuits in health and disease

article The logic of developing neocortical circuits in health and disease published yes Ileana L. Hanganu-Opatz author Simon J. B. Butt author Simon Hippenmeyer author 37B36620-F248-11E8-B48F-1D18A9856A870000-0003-2279-1061 Natalia V. De Marco García author Jessica A. Cardin author Bradley Voytek author Alysson R. Muotri author SiHi department Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development project Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular Mechanisms of Neural Stem Cell Lineage Progression project The sensory and cognitive abilities of the mammalian neocortex are underpinned by intricate columnar and laminar circuits formed from an array of diverse neuronal populations. One approach to determining how interactions between these circuit components give rise to complex behavior is to investigate the rules by which cortical circuits are formed and acquire functionality during development. This review summarizes recent research on the development of the neocortex, from genetic determination in neural stem cells through to the dynamic role that specific neuronal populations play in the earliest circuits of neocortex, and how they contribute to emergent function and cognition. While many of these endeavors take advantage of model systems, consideration will also be given to advances in our understanding of activity in nascent human circuits. Such cross-species perspective is imperative when investigating the mechanisms underlying the dysfunction of early neocortical circuits in neurodevelopmental disorders, so that one can identify targets amenable to therapeutic intervention. https://research-explorer.ista.ac.at/download/9073/11414/2021_JourNeuroscience_Hanganu.pdf application/pdfno Society for Neuroscience2021 eng General Neuroscience The Journal of Neuroscience 0270-6474 1529-2401 33431633 00061676340000210.1523/jneurosci.1655-20.2020 415813-822 Hanganu-Opatz, Ileana L., Simon J. B. Butt, Simon Hippenmeyer, Natalia V. De Marco García, Jessica A. Cardin, Bradley Voytek, and Alysson R. Muotri. “The Logic of Developing Neocortical Circuits in Health and Disease.” The Journal of Neuroscience. Society for Neuroscience, 2021. <a href="https://doi.org/10.1523/jneurosci.1655-20.2020">https://doi.org/10.1523/jneurosci.1655-20.2020</a>. I. L. Hanganu-Opatz et al., “The logic of developing neocortical circuits in health and disease,” The Journal of Neuroscience, vol. 41, no. 5. Society for Neuroscience, pp. 813–822, 2021. I.L. Hanganu-Opatz, S.J.B. Butt, S. Hippenmeyer, N.V. De Marco García, J.A. Cardin, B. Voytek, A.R. Muotri, The Journal of Neuroscience 41 (2021) 813–822. Hanganu-Opatz, Ileana L., et al. “The Logic of Developing Neocortical Circuits in Health and Disease.” The Journal of Neuroscience, vol. 41, no. 5, Society for Neuroscience, 2021, pp. 813–22, doi:<a href="https://doi.org/10.1523/jneurosci.1655-20.2020">10.1523/jneurosci.1655-20.2020</a>. Hanganu-Opatz IL, Butt SJB, Hippenmeyer S, De Marco García NV, Cardin JA, Voytek B, Muotri AR. 2021. The logic of developing neocortical circuits in health and disease. The Journal of Neuroscience. 41(5), 813–822. Hanganu-Opatz, I. L., Butt, S. J. B., Hippenmeyer, S., De Marco García, N. V., Cardin, J. A., Voytek, B., & Muotri, A. R. (2021). The logic of developing neocortical circuits in health and disease. The Journal of Neuroscience. Society for Neuroscience. <a href="https://doi.org/10.1523/jneurosci.1655-20.2020">https://doi.org/10.1523/jneurosci.1655-20.2020</a> Hanganu-Opatz IL, Butt SJB, Hippenmeyer S, et al. The logic of developing neocortical circuits in health and disease. The Journal of Neuroscience. 2021;41(5):813-822. doi:<a href="https://doi.org/10.1523/jneurosci.1655-20.2020">10.1523/jneurosci.1655-20.2020</a> 90732021-02-03T12:23:51Z2025-04-15T08:23:06Z