---
_id: '9073'
abstract:
- lang: eng
  text: The sensory and cognitive abilities of the mammalian neocortex are underpinned
    by intricate columnar and laminar circuits formed from an array of diverse neuronal
    populations. One approach to determining how interactions between these circuit
    components give rise to complex behavior is to investigate the rules by which
    cortical circuits are formed and acquire functionality during development. This
    review summarizes recent research on the development of the neocortex, from genetic
    determination in neural stem cells through to the dynamic role that specific neuronal
    populations play in the earliest circuits of neocortex, and how they contribute
    to emergent function and cognition. While many of these endeavors take advantage
    of model systems, consideration will also be given to advances in our understanding
    of activity in nascent human circuits. Such cross-species perspective is imperative
    when investigating the mechanisms underlying the dysfunction of early neocortical
    circuits in neurodevelopmental disorders, so that one can identify targets amenable
    to therapeutic intervention.
acknowledgement: Work in the I.L.H.-O. laboratory was supported by European Research
  Council Grant ERC-2015-CoG 681577 and German Research Foundation Ha 4466/10-1, Ha4466/11-1,
  Ha4466/12-1, SPP 1665, and SFB 936B5. Work in the S.J.B.B. laboratory was supported
  by Biotechnology and Biological Sciences Research Council BB/P003796/1, Medical
  Research Council MR/K004387/1 and MR/T033320/1, Wellcome Trust 215199/Z/19/Z and
  102386/Z/13/Z, and John Fell Fund. Work in the S.H. laboratory was supported by
  European Research Council Grants ERC-2016-CoG 725780 LinPro and FWF SFB F78. This
  work was supported by National Institutes of Health Grant NIMH 1R01MH110553 to N.V.D.M.G.
  Work in the J.A.C. laboratory was supported by the Ludwig Family Foundation, Simons
  Foundation SFARI Research Award, and National Institutes of Health/National Institute
  of Mental Health R01 MH102365 and R01MH113852. The B.V. laboratory was supported
  by Whitehall Foundation 2017-12-73, National Science Foundation 1736028, National
  Institutes of Health, National Institute of General Medical Sciences R01GM134363-01,
  and Halıcıoğlu Data Science Institute Fellowship. This work was supported by the
  University of California San Diego School of Medicine.
article_processing_charge: No
article_type: original
author:
- first_name: Ileana L.
  full_name: Hanganu-Opatz, Ileana L.
  last_name: Hanganu-Opatz
- first_name: Simon J. B.
  full_name: Butt, Simon J. B.
  last_name: Butt
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Natalia V.
  full_name: De Marco García, Natalia V.
  last_name: De Marco García
- first_name: Jessica A.
  full_name: Cardin, Jessica A.
  last_name: Cardin
- first_name: Bradley
  full_name: Voytek, Bradley
  last_name: Voytek
- first_name: Alysson R.
  full_name: Muotri, Alysson R.
  last_name: Muotri
citation:
  ama: Hanganu-Opatz IL, Butt SJB, Hippenmeyer S, et al. The logic of developing neocortical
    circuits in health and disease. <i>The Journal of Neuroscience</i>. 2021;41(5):813-822.
    doi:<a href="https://doi.org/10.1523/jneurosci.1655-20.2020">10.1523/jneurosci.1655-20.2020</a>
  apa: Hanganu-Opatz, I. L., Butt, S. J. B., Hippenmeyer, S., De Marco García, N.
    V., Cardin, J. A., Voytek, B., &#38; Muotri, A. R. (2021). The logic of developing
    neocortical circuits in health and disease. <i>The Journal of Neuroscience</i>.
    Society for Neuroscience. <a href="https://doi.org/10.1523/jneurosci.1655-20.2020">https://doi.org/10.1523/jneurosci.1655-20.2020</a>
  chicago: Hanganu-Opatz, Ileana L., Simon J. B. Butt, Simon Hippenmeyer, Natalia
    V. De Marco García, Jessica A. Cardin, Bradley Voytek, and Alysson R. Muotri.
    “The Logic of Developing Neocortical Circuits in Health and Disease.” <i>The Journal
    of Neuroscience</i>. Society for Neuroscience, 2021. <a href="https://doi.org/10.1523/jneurosci.1655-20.2020">https://doi.org/10.1523/jneurosci.1655-20.2020</a>.
  ieee: I. L. Hanganu-Opatz <i>et al.</i>, “The logic of developing neocortical circuits
    in health and disease,” <i>The Journal of Neuroscience</i>, vol. 41, no. 5. Society
    for Neuroscience, pp. 813–822, 2021.
  ista: Hanganu-Opatz IL, Butt SJB, Hippenmeyer S, De Marco García NV, Cardin JA,
    Voytek B, Muotri AR. 2021. The logic of developing neocortical circuits in health
    and disease. The Journal of Neuroscience. 41(5), 813–822.
  mla: Hanganu-Opatz, Ileana L., et al. “The Logic of Developing Neocortical Circuits
    in Health and Disease.” <i>The Journal of Neuroscience</i>, vol. 41, no. 5, Society
    for Neuroscience, 2021, pp. 813–22, doi:<a href="https://doi.org/10.1523/jneurosci.1655-20.2020">10.1523/jneurosci.1655-20.2020</a>.
  short: I.L. Hanganu-Opatz, S.J.B. Butt, S. Hippenmeyer, N.V. De Marco García, J.A.
    Cardin, B. Voytek, A.R. Muotri, The Journal of Neuroscience 41 (2021) 813–822.
date_created: 2021-02-03T12:23:51Z
date_published: 2021-02-03T00:00:00Z
date_updated: 2025-04-15T08:23:06Z
day: '03'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1523/jneurosci.1655-20.2020
ec_funded: 1
external_id:
  isi:
  - '000616763400002'
  pmid:
  - '33431633'
file:
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  creator: dernst
  date_created: 2022-05-27T06:59:55Z
  date_updated: 2022-05-27T06:59:55Z
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file_date_updated: 2022-05-27T06:59:55Z
has_accepted_license: '1'
intvolume: '        41'
isi: 1
issue: '5'
keyword:
- General Neuroscience
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 813-822
pmid: 1
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '725780'
  name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
- _id: 059F6AB4-7A3F-11EA-A408-12923DDC885E
  grant_number: F7805
  name: Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular
    Mechanisms of Neural Stem Cell Lineage Progression
publication: The Journal of Neuroscience
publication_identifier:
  eissn:
  - 1529-2401
  issn:
  - 0270-6474
publication_status: published
publisher: Society for Neuroscience
quality_controlled: '1'
scopus_import: '1'
status: public
title: The logic of developing neocortical circuits in health and disease
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 41
year: '2021'
...