---
res:
  bibo_abstract:
  - Acquired mutations are sufficiently frequent such that the genome of a single
    cell offers a record of its history of cell divisions. Among more common somatic
    genomic alterations are loss of heterozygosity (LOH). Large LOH events are potentially
    detectable in single cell RNA sequencing (scRNA-seq) datasets as tracts of monoallelic
    expression for constitutionally heterozygous single nucleotide variants (SNVs)
    located among contiguous genes. We identified runs of monoallelic expression,
    consistent with LOH, uniquely distributed throughout the genome in single cell
    brain cortex transcriptomes of F1 hybrids involving different inbred mouse strains.
    We then phylogenetically reconstructed single cell lineages and simultaneously
    identified cell types by corresponding gene expression patterns. Our results are
    consistent with progenitor cells giving rise to multiple cortical cell types through
    stereotyped expansion and distinct waves of neurogenesis. Compared to engineered
    recording systems, LOH events accumulate throughout the genome and across the
    lifetime of an organism, affording tremendous capacity for encoding lineage information
    and increasing resolution for later cell divisions. This approach can conceivably
    be computationally incorporated into scRNA-seq analysis and may be useful for
    organisms where genetic engineering is prohibitive, such as humans.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Donovan J.
      foaf_name: Anderson, Donovan J.
      foaf_surname: Anderson
  - foaf_Person:
      foaf_givenName: Florian
      foaf_name: Pauler, Florian
      foaf_surname: Pauler
      foaf_workInfoHomepage: http://www.librecat.org/personId=48EA0138-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-7462-0048
  - foaf_Person:
      foaf_givenName: Aaron
      foaf_name: McKenna, Aaron
      foaf_surname: McKenna
  - foaf_Person:
      foaf_givenName: Jay
      foaf_name: Shendure, Jay
      foaf_surname: Shendure
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Hippenmeyer, Simon
      foaf_surname: Hippenmeyer
      foaf_workInfoHomepage: http://www.librecat.org/personId=37B36620-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2279-1061
  - foaf_Person:
      foaf_givenName: Marshall S.
      foaf_name: Horwitz, Marshall S.
      foaf_surname: Horwitz
  bibo_doi: 10.1101/2020.12.31.425016
  dct_date: 2021^xs_gYear
  dct_language: eng
  dct_publisher: Cold Spring Harbor Laboratory@
  dct_title: Simultaneous identification of brain cell type and lineage via single
    cell RNA sequencing@
...