---
res:
  bibo_abstract:
  - Dendritic cells (DCs) are crucial for the priming of naive T cells and the initiation
    of adaptive immunity. Priming is initiated at a heterologous cell–cell contact,
    the immunological synapse (IS). While it is established that F-actin dynamics
    regulates signaling at the T cell side of the contact, little is known about the
    cytoskeletal contribution on the DC side. Here, we show that the DC actin cytoskeleton
    is decisive for the formation of a multifocal synaptic structure, which correlates
    with T cell priming efficiency. DC actin at the IS appears in transient foci that
    are dynamized by the WAVE regulatory complex (WRC). The absence of the WRC in
    DCs leads to stabilized contacts with T cells, caused by an increase in ICAM1-integrin–mediated
    cell–cell adhesion. This results in lower numbers of activated and proliferating
    T cells, demonstrating an important role for DC actin in the regulation of immune
    synapse functionality.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Alexander F
      foaf_name: Leithner, Alexander F
      foaf_surname: Leithner
      foaf_workInfoHomepage: http://www.librecat.org/personId=3B1B77E4-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-1073-744X
  - foaf_Person:
      foaf_givenName: LM
      foaf_name: Altenburger, LM
      foaf_surname: Altenburger
  - foaf_Person:
      foaf_givenName: R
      foaf_name: Hauschild, R
      foaf_surname: Hauschild
  - foaf_Person:
      foaf_givenName: Frank P
      foaf_name: Assen, Frank P
      foaf_surname: Assen
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A8E7F24-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-3470-6119
  - foaf_Person:
      foaf_givenName: K
      foaf_name: Rottner, K
      foaf_surname: Rottner
  - foaf_Person:
      foaf_givenName: Stradal
      foaf_name: TEB, Stradal
      foaf_surname: TEB
  - foaf_Person:
      foaf_givenName: A
      foaf_name: Diz-Muñoz, A
      foaf_surname: Diz-Muñoz
  - foaf_Person:
      foaf_givenName: JV
      foaf_name: Stein, JV
      foaf_surname: Stein
  - foaf_Person:
      foaf_givenName: Michael K
      foaf_name: Sixt, Michael K
      foaf_surname: Sixt
      foaf_workInfoHomepage: http://www.librecat.org/personId=41E9FBEA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6620-9179
  bibo_doi: 10.1083/jcb.202006081
  bibo_issue: '4'
  bibo_volume: 220
  dct_date: 2021^xs_gYear
  dct_identifier:
  - UT:000626365700001
  dct_isPartOf:
  - http://id.crossref.org/issn/0021-9525
  - http://id.crossref.org/issn/1540-8140
  dct_language: eng
  dct_publisher: Rockefeller University Press@
  dct_title: Dendritic cell actin dynamics control contact duration and priming efficiency
    at the immunological synapse@
  fabio_hasPubmedId: '33533935'
...