--- res: bibo_abstract: - Coordinated cell polarization in developing tissues is a recurrent theme in multicellular organisms. In plants, a directional distribution of the plant hormone auxin is at the core of many developmental programs. A feedback regulation of auxin on the polarized localization of PIN auxin transporters in individual cells has been proposed as a self-organizing mechanism for coordinated tissue polarization, but the molecular mechanisms linking auxin signalling to PIN-dependent auxin transport remain unknown. We performed a microarray-based approach to find regulators of the auxin-induced PIN relocation in the Arabidopsis thaliana root. We identified a subset of a family of phosphatidylinositol transfer proteins (PITP), the PATELLINs (PATL). Here, we show that PATLs are expressed in partially overlapping cells types in different tissues going through mitosis or initiating differentiation programs. PATLs are plasma membrane-associated proteins accumulated in Arabidopsis embryos, primary roots, lateral root primordia, and developing stomata. Higher order patl mutants display reduced PIN1 repolarization in response to auxin, shorter root apical meristem, and drastic defects in embryo and seedling development. This suggests PATLs redundantly play a crucial role in polarity and patterning in Arabidopsis.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Ricardo foaf_name: Tejos, Ricardo foaf_surname: Tejos - foaf_Person: foaf_givenName: Cecilia foaf_name: Rodríguez Furlán, Cecilia foaf_surname: Rodríguez Furlán - foaf_Person: foaf_givenName: Maciek foaf_name: Adamowski, Maciek foaf_surname: Adamowski foaf_workInfoHomepage: http://www.librecat.org/personId=45F536D2-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-6463-5257 - foaf_Person: foaf_givenName: Michael foaf_name: Sauer, Michael foaf_surname: Sauer - foaf_Person: foaf_givenName: Lorena foaf_name: Norambuena, Lorena foaf_surname: Norambuena - foaf_Person: foaf_givenName: Jirí foaf_name: Friml, Jirí foaf_surname: Friml foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8302-7596 bibo_doi: 10.1242/jcs.204198 bibo_issue: '2' bibo_volume: 131 dct_date: 2018^xs_gYear dct_identifier: - UT:000424842400019 dct_isPartOf: - http://id.crossref.org/issn/00219533 dct_language: eng dct_publisher: Company of Biologists@ dct_title: PATELLINS are regulators of auxin mediated PIN1 relocation and plant development in Arabidopsis thaliana@ ...