{"article_processing_charge":"No","ec_funded":1,"type":"journal_article","page":"51-67","publisher":"De Gruyter","publication_status":"published","department":[{"_id":"HeEd"}],"date_updated":"2023-10-17T12:34:51Z","year":"2020","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"file_date_updated":"2021-02-19T13:56:24Z","date_published":"2020-06-20T00:00:00Z","project":[{"_id":"266A2E9E-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"788183","name":"Alpha Shape Theory Extended"},{"name":"Persistence and stability of geometric complexes","grant_number":"I02979-N35","_id":"2561EBF4-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"language":[{"iso":"eng"}],"quality_controlled":"1","oa":1,"article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["2544-7297"]},"month":"06","doi":"10.1515/cmb-2020-0100","abstract":[{"text":"Representing an atom by a solid sphere in 3-dimensional Euclidean space, we get the space-filling diagram of a molecule by taking the union. Molecular dynamics simulates its motion subject to bonds and other forces, including the solvation free energy. The morphometric approach [12, 17] writes the latter as a linear combination of weighted versions of the volume, area, mean curvature, and Gaussian curvature of the space-filling diagram. We give a formula for the derivative of the weighted mean curvature. Together with the derivatives of the weighted volume in [7], the weighted area in [3], and the weighted Gaussian curvature [1], this yields the derivative of the morphometric expression of the solvation free energy.","lang":"eng"}],"ddc":["510"],"acknowledgement":"The authors of this paper thank Roland Roth for suggesting the analysis of the weighted\r\ncurvature derivatives for the purpose of improving molecular dynamics simulations and for his continued encouragement. They also thank Patrice Koehl for the implementation of the formulas and for his encouragement and advise along the road. Finally, they thank two anonymous reviewers for their constructive criticism.\r\nThis project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 78818 Alpha). It is also partially supported by the DFG Collaborative Research Center TRR 109, ‘Discretization in Geometry and Dynamics’, through grant no. I02979-N35 of the Austrian Science Fund (FWF).","has_accepted_license":"1","_id":"9157","status":"public","oa_version":"Published Version","volume":8,"publication":"Computational and Mathematical Biophysics","file":[{"file_id":"9171","success":1,"creator":"dernst","checksum":"cea41de9937d07a3b927d71ee8b4e432","content_type":"application/pdf","file_name":"2020_CompMathBiophysics_Akopyan2.pdf","date_updated":"2021-02-19T13:56:24Z","relation":"main_file","access_level":"open_access","file_size":562359,"date_created":"2021-02-19T13:56:24Z"}],"issue":"1","citation":{"mla":"Akopyan, Arseniy, and Herbert Edelsbrunner. “The Weighted Mean Curvature Derivative of a Space-Filling Diagram.” <i>Computational and Mathematical Biophysics</i>, vol. 8, no. 1, De Gruyter, 2020, pp. 51–67, doi:<a href=\"https://doi.org/10.1515/cmb-2020-0100\">10.1515/cmb-2020-0100</a>.","apa":"Akopyan, A., &#38; Edelsbrunner, H. (2020). The weighted mean curvature derivative of a space-filling diagram. <i>Computational and Mathematical Biophysics</i>. De Gruyter. <a href=\"https://doi.org/10.1515/cmb-2020-0100\">https://doi.org/10.1515/cmb-2020-0100</a>","ieee":"A. Akopyan and H. Edelsbrunner, “The weighted mean curvature derivative of a space-filling diagram,” <i>Computational and Mathematical Biophysics</i>, vol. 8, no. 1. De Gruyter, pp. 51–67, 2020.","ama":"Akopyan A, Edelsbrunner H. The weighted mean curvature derivative of a space-filling diagram. <i>Computational and Mathematical Biophysics</i>. 2020;8(1):51-67. doi:<a href=\"https://doi.org/10.1515/cmb-2020-0100\">10.1515/cmb-2020-0100</a>","ista":"Akopyan A, Edelsbrunner H. 2020. The weighted mean curvature derivative of a space-filling diagram. Computational and Mathematical Biophysics. 8(1), 51–67.","short":"A. Akopyan, H. Edelsbrunner, Computational and Mathematical Biophysics 8 (2020) 51–67.","chicago":"Akopyan, Arseniy, and Herbert Edelsbrunner. “The Weighted Mean Curvature Derivative of a Space-Filling Diagram.” <i>Computational and Mathematical Biophysics</i>. De Gruyter, 2020. <a href=\"https://doi.org/10.1515/cmb-2020-0100\">https://doi.org/10.1515/cmb-2020-0100</a>."},"day":"20","title":"The weighted mean curvature derivative of a space-filling diagram","intvolume":"         8","author":[{"orcid":"0000-0002-2548-617X","last_name":"Akopyan","id":"430D2C90-F248-11E8-B48F-1D18A9856A87","full_name":"Akopyan, Arseniy","first_name":"Arseniy"},{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Edelsbrunner, Herbert","last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833","first_name":"Herbert"}],"date_created":"2021-02-17T15:13:01Z"}