---
res:
  bibo_abstract:
  - Genomic imprinting is an epigenetic mechanism that results in parental allele-specific
    expression of ~1% of all genes in mouse and human. Imprinted genes are key developmental
    regulators and play pivotal roles in many biological processes such as nutrient
    transfer from the mother to offspring and neuronal development. Imprinted genes
    are also involved in human disease, including neurodevelopmental disorders, and
    often occur in clusters that are regulated by a common imprint control region
    (ICR). In extra-embryonic tissues ICRs can act over large distances, with the
    largest surrounding Igf2r spanning over 10 million base-pairs. Besides classical
    imprinted expression that shows near exclusive maternal or paternal expression,
    widespread biased imprinted expression has been identified mainly in brain. In
    this review we discuss recent developments mapping cell type specific imprinted
    expression in extra-embryonic tissues and neocortex in the mouse. We highlight
    the advantages of using an inducible uniparental chromosome disomy (UPD) system
    to generate cells carrying either two maternal or two paternal copies of a specific
    chromosome to analyze the functional consequences of genomic imprinting. Mosaic
    Analysis with Double Markers (MADM) allows fluorescent labeling and concomitant
    induction of UPD sparsely in specific cell types, and thus to over-express or
    suppress all imprinted genes on that chromosome. To illustrate the utility of
    this technique, we explain how MADM-induced UPD revealed new insights about the
    function of the well-studied Cdkn1c imprinted gene, and how MADM-induced UPDs
    led to identification of highly cell type specific phenotypes related to perturbed
    imprinted expression in the mouse neocortex. Finally, we give an outlook on how
    MADM could be used to probe cell type specific imprinted expression in other tissues
    in mouse, particularly in extra-embryonic tissues.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Florian
      foaf_name: Pauler, Florian
      foaf_surname: Pauler
      foaf_workInfoHomepage: http://www.librecat.org/personId=48EA0138-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-7462-0048
  - foaf_Person:
      foaf_givenName: Quanah
      foaf_name: Hudson, Quanah
      foaf_surname: Hudson
  - foaf_Person:
      foaf_givenName: Susanne
      foaf_name: Laukoter, Susanne
      foaf_surname: Laukoter
      foaf_workInfoHomepage: http://www.librecat.org/personId=2D6B7A9A-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-7903-3010
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Hippenmeyer, Simon
      foaf_surname: Hippenmeyer
      foaf_workInfoHomepage: http://www.librecat.org/personId=37B36620-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2279-1061
  bibo_doi: 10.1016/j.neuint.2021.104986
  bibo_issue: '5'
  bibo_volume: 145
  dct_date: 2021^xs_gYear
  dct_identifier:
  - UT:000635575000005
  dct_isPartOf:
  - http://id.crossref.org/issn/0197-0186
  dct_language: eng
  dct_publisher: Elsevier@
  dct_subject:
  - Cell Biology
  - Cellular and Molecular Neuroscience
  dct_title: Inducible uniparental chromosome disomy to probe genomic imprinting at
    single-cell level in brain and beyond@
  fabio_hasPubmedId: '33600873'
...