--- res: bibo_abstract: - Sequence-specific oligomers with predictable folding patterns, i.e., foldamers, provide new opportunities to mimic α-helical peptides and design inhibitors of protein-protein interactions. One major hurdle of this strategy is to retain the correct orientation of key side chains involved in protein surface recognition. Here, we show that the structural plasticity of a foldamer backbone may notably contribute to the required spatial adjustment for optimal interaction with the protein surface. By using oligoureas as α helix mimics, we designed a foldamer/peptide hybrid inhibitor of histone chaperone ASF1, a key regulator of chromatin dynamics. The crystal structure of its complex with ASF1 reveals a notable plasticity of the urea backbone, which adapts to the ASF1 surface to maintain the same binding interface. One additional benefit of generating ASF1 ligands with nonpeptide oligourea segments is the resistance to proteolysis in human plasma, which was highly improved compared to the cognate α-helical peptide.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Johanne foaf_name: Mbianda, Johanne foaf_surname: Mbianda - foaf_Person: foaf_givenName: May M foaf_name: Bakail, May M foaf_surname: Bakail foaf_workInfoHomepage: http://www.librecat.org/personId=FB3C3F8E-522F-11EA-B186-22963DDC885E orcid: 0000-0002-9592-1587 - foaf_Person: foaf_givenName: Christophe foaf_name: André, Christophe foaf_surname: André - foaf_Person: foaf_givenName: Gwenaëlle foaf_name: Moal, Gwenaëlle foaf_surname: Moal - foaf_Person: foaf_givenName: Marie E. foaf_name: Perrin, Marie E. foaf_surname: Perrin - foaf_Person: foaf_givenName: Guillaume foaf_name: Pinna, Guillaume foaf_surname: Pinna - foaf_Person: foaf_givenName: Raphaël foaf_name: Guerois, Raphaël foaf_surname: Guerois - foaf_Person: foaf_givenName: Francois foaf_name: Becher, Francois foaf_surname: Becher - foaf_Person: foaf_givenName: Pierre foaf_name: Legrand, Pierre foaf_surname: Legrand - foaf_Person: foaf_givenName: Seydou foaf_name: Traoré, Seydou foaf_surname: Traoré - foaf_Person: foaf_givenName: Céline foaf_name: Douat, Céline foaf_surname: Douat - foaf_Person: foaf_givenName: Gilles foaf_name: Guichard, Gilles foaf_surname: Guichard - foaf_Person: foaf_givenName: Françoise foaf_name: Ochsenbein, Françoise foaf_surname: Ochsenbein bibo_doi: 10.1126/sciadv.abd9153 bibo_issue: '12' bibo_volume: 7 dct_date: 2021^xs_gYear dct_identifier: - UT:000633443000011 dct_isPartOf: - http://id.crossref.org/issn/2375-2548 dct_language: eng dct_publisher: American Association for the Advancement of Science@ dct_title: Optimal anchoring of a foldamer inhibitor of ASF1 histone chaperone through backbone plasticity@ fabio_hasPubmedId: '33741589' ...