---
res:
  bibo_abstract:
  - Gene expression levels are influenced by multiple coexisting molecular mechanisms.
    Some of these interactions such as those of transcription factors and promoters
    have been studied extensively. However, predicting phenotypes of gene regulatory
    networks (GRNs) remains a major challenge. Here, we use a well-defined synthetic
    GRN to study in Escherichia coli how network phenotypes depend on local genetic
    context, i.e. the genetic neighborhood of a transcription factor and its relative
    position. We show that one GRN with fixed topology can display not only quantitatively
    but also qualitatively different phenotypes, depending solely on the local genetic
    context of its components. Transcriptional read-through is the main molecular
    mechanism that places one transcriptional unit (TU) within two separate regulons
    without the need for complex regulatory sequences. We propose that relative order
    of individual TUs, with its potential for combinatorial complexity, plays an important
    role in shaping phenotypes of GRNs.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Anna A
      foaf_name: Nagy-Staron, Anna A
      foaf_surname: Nagy-Staron
      foaf_workInfoHomepage: http://www.librecat.org/personId=3ABC5BA6-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-1391-8377
  - foaf_Person:
      foaf_givenName: Kathrin
      foaf_name: Tomasek, Kathrin
      foaf_surname: Tomasek
      foaf_workInfoHomepage: http://www.librecat.org/personId=3AEC8556-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-3768-877X
  - foaf_Person:
      foaf_givenName: Caroline
      foaf_name: Caruso Carter, Caroline
      foaf_surname: Caruso Carter
  - foaf_Person:
      foaf_givenName: Elisabeth
      foaf_name: Sonnleitner, Elisabeth
      foaf_surname: Sonnleitner
  - foaf_Person:
      foaf_givenName: Bor
      foaf_name: Kavcic, Bor
      foaf_surname: Kavcic
      foaf_workInfoHomepage: http://www.librecat.org/personId=350F91D2-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6041-254X
  - foaf_Person:
      foaf_givenName: Tiago
      foaf_name: Paixão, Tiago
      foaf_surname: Paixão
  - foaf_Person:
      foaf_givenName: Calin C
      foaf_name: Guet, Calin C
      foaf_surname: Guet
      foaf_workInfoHomepage: http://www.librecat.org/personId=47F8433E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6220-2052
  bibo_doi: 10.7554/elife.65993
  bibo_volume: 10
  dct_date: 2021^xs_gYear
  dct_identifier:
  - UT:000631050900001
  dct_isPartOf:
  - http://id.crossref.org/issn/2050-084X
  dct_language: eng
  dct_publisher: eLife Sciences Publications@
  dct_subject:
  - Genetics and Molecular Biology
  dct_title: Local genetic context shapes the function of a gene regulatory network@
  fabio_hasPubmedId: '33683203'
...