--- res: bibo_abstract: - Although collective cell motion plays an important role, for example during wound healing, embryogenesis, or cancer progression, the fundamental rules governing this motion are still not well understood, in particular at high cell density. We study here the motion of human bronchial epithelial cells within a monolayer, over long times. We observe that, as the monolayer ages, the cells slow down monotonously, while the velocity correlation length first increases as the cells slow down but eventually decreases at the slowest motions. By comparing experiments, analytic model, and detailed particle-based simulations, we shed light on this biological amorphous solidification process, demonstrating that the observed dynamics can be explained as a consequence of the combined maturation and strengthening of cell-cell and cell-substrate adhesions. Surprisingly, the increase of cell surface density due to proliferation is only secondary in this process. This analysis is confirmed with two other cell types. The very general relations between the mean cell velocity and velocity correlation lengths, which apply for aggregates of self-propelled particles, as well as motile cells, can possibly be used to discriminate between various parameter changes in vivo, from noninvasive microscopy data.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Simón foaf_name: García, Simón foaf_surname: García - foaf_Person: foaf_givenName: Edouard B foaf_name: Hannezo, Edouard B foaf_surname: Hannezo foaf_workInfoHomepage: http://www.librecat.org/personId=3A9DB764-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-6005-1561 - foaf_Person: foaf_givenName: Jens foaf_name: Elgeti, Jens foaf_surname: Elgeti - foaf_Person: foaf_givenName: Jean foaf_name: Joanny, Jean foaf_surname: Joanny - foaf_Person: foaf_givenName: Pascal foaf_name: Silberzan, Pascal foaf_surname: Silberzan - foaf_Person: foaf_givenName: Nir foaf_name: Gov, Nir foaf_surname: Gov bibo_doi: 10.1073/pnas.1510973112 bibo_issue: '50' bibo_volume: 112 dct_date: 2015^xs_gYear dct_language: eng dct_publisher: National Academy of Sciences@ dct_title: Physics of active jamming during collective cellular motion in a monolayer@ fabio_hasPubmedId: '26627719' ...