---
_id: '9332'
abstract:
- lang: eng
  text: Lateral root (LR) formation is an example of a plant post-embryonic organogenesis
    event. LRs are issued from non-dividing cells entering consecutive steps of formative
    divisions, proliferation and elongation. The chromatin remodeling protein PICKLE
    (PKL) negatively regulates auxin-mediated LR formation through a mechanism that
    is not yet known. Here we show that PKL interacts with RETINOBLASTOMA-RELATED
    1 (RBR1) to repress the LATERAL ORGAN BOUNDARIES-DOMAIN 16 (LBD16) promoter activity.
    Since LBD16 function is required for the formative division of LR founder cells,
    repression mediated by the PKL–RBR1 complex negatively regulates formative division
    and LR formation. Inhibition of LR formation by PKL–RBR1 is counteracted by auxin,
    indicating that, in addition to auxin-mediated transcriptional responses, the
    fine-tuned process of LR formation is also controlled at the chromatin level in
    an auxin-signaling dependent manner.
acknowledgement: "This research was supported by a postdoctoral fellowship of the
  Carl Tryggers Foundation (to K.Ö.) and by grants from Vetenskapsrådet (Nr.: 621-2004-2921
  to L.B.) and VINNOVA (to L.B. and S.R.).\r\nWe thank Frederic Berger, Hidehiro Fukaki,
  Malcolm Bennett, Claudia Köhler, Jiri Friml for providing pRBR1::RBR1-RFP, ssl2-1,
  slr-1, pPKL::PKL-GFP seeds and the DR5 expressing vector, respectively. Authors
  are grateful to Hayashi Kenichiro for providing the auxinol compound and to Rishi
  Bhalerao for stimulating discussions. The technical help of Adeline Rigal and Thomas
  Vain with the auxinol experiments is much appreciated."
article_number: '3862'
article_processing_charge: No
article_type: original
author:
- first_name: Krisztina
  full_name: Ötvös, Krisztina
  id: 29B901B0-F248-11E8-B48F-1D18A9856A87
  last_name: Ötvös
  orcid: 0000-0002-5503-4983
- first_name: Pál
  full_name: Miskolczi, Pál
  last_name: Miskolczi
- first_name: Peter
  full_name: Marhavý, Peter
  id: 3F45B078-F248-11E8-B48F-1D18A9856A87
  last_name: Marhavý
  orcid: 0000-0001-5227-5741
- first_name: Alfredo
  full_name: Cruz-Ramírez, Alfredo
  last_name: Cruz-Ramírez
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
- first_name: Stéphanie
  full_name: Robert, Stéphanie
  last_name: Robert
- first_name: László
  full_name: Bakó, László
  last_name: Bakó
citation:
  ama: Ötvös K, Miskolczi P, Marhavý P, et al. Pickle recruits retinoblastoma related
    1 to control lateral root formation in arabidopsis. <i>International Journal of
    Molecular Sciences</i>. 2021;22(8). doi:<a href="https://doi.org/10.3390/ijms22083862">10.3390/ijms22083862</a>
  apa: Ötvös, K., Miskolczi, P., Marhavý, P., Cruz-Ramírez, A., Benková, E., Robert,
    S., &#38; Bakó, L. (2021). Pickle recruits retinoblastoma related 1 to control
    lateral root formation in arabidopsis. <i>International Journal of Molecular Sciences</i>.
    MDPI. <a href="https://doi.org/10.3390/ijms22083862">https://doi.org/10.3390/ijms22083862</a>
  chicago: Ötvös, Krisztina, Pál Miskolczi, Peter Marhavý, Alfredo Cruz-Ramírez, Eva
    Benková, Stéphanie Robert, and László Bakó. “Pickle Recruits Retinoblastoma Related
    1 to Control Lateral Root Formation in Arabidopsis.” <i>International Journal
    of Molecular Sciences</i>. MDPI, 2021. <a href="https://doi.org/10.3390/ijms22083862">https://doi.org/10.3390/ijms22083862</a>.
  ieee: K. Ötvös <i>et al.</i>, “Pickle recruits retinoblastoma related 1 to control
    lateral root formation in arabidopsis,” <i>International Journal of Molecular
    Sciences</i>, vol. 22, no. 8. MDPI, 2021.
  ista: Ötvös K, Miskolczi P, Marhavý P, Cruz-Ramírez A, Benková E, Robert S, Bakó
    L. 2021. Pickle recruits retinoblastoma related 1 to control lateral root formation
    in arabidopsis. International Journal of Molecular Sciences. 22(8), 3862.
  mla: Ötvös, Krisztina, et al. “Pickle Recruits Retinoblastoma Related 1 to Control
    Lateral Root Formation in Arabidopsis.” <i>International Journal of Molecular
    Sciences</i>, vol. 22, no. 8, 3862, MDPI, 2021, doi:<a href="https://doi.org/10.3390/ijms22083862">10.3390/ijms22083862</a>.
  short: K. Ötvös, P. Miskolczi, P. Marhavý, A. Cruz-Ramírez, E. Benková, S. Robert,
    L. Bakó, International Journal of Molecular Sciences 22 (2021).
date_created: 2021-04-18T22:01:41Z
date_published: 2021-04-08T00:00:00Z
date_updated: 2025-06-12T06:39:41Z
day: '08'
ddc:
- '570'
department:
- _id: EvBe
doi: 10.3390/ijms22083862
external_id:
  isi:
  - '000644394800001'
  pmid:
  - '33917959'
file:
- access_level: open_access
  checksum: 26ada2531ad1f9c01a1664de0431f1fe
  content_type: application/pdf
  creator: dernst
  date_created: 2021-04-19T10:54:55Z
  date_updated: 2021-04-19T10:54:55Z
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  file_name: 2021_JourMolecularScience_Oetvoes.pdf
  file_size: 2769717
  relation: main_file
  success: 1
file_date_updated: 2021-04-19T10:54:55Z
has_accepted_license: '1'
intvolume: '        22'
isi: 1
issue: '8'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
publication: International Journal of Molecular Sciences
publication_identifier:
  eissn:
  - 1422-0067
  issn:
  - 1661-6596
publication_status: published
publisher: MDPI
quality_controlled: '1'
scopus_import: '1'
status: public
title: Pickle recruits retinoblastoma related 1 to control lateral root formation
  in arabidopsis
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2021'
...