--- res: bibo_abstract: - 'The way in which interactions between mechanics and biochemistry lead to the emergence of complex cell and tissue organization is an old question that has recently attracted renewed interest from biologists, physicists, mathematicians and computer scientists. Rapid advances in optical physics, microscopy and computational image analysis have greatly enhanced our ability to observe and quantify spatiotemporal patterns of signalling, force generation, deformation, and flow in living cells and tissues. Powerful new tools for genetic, biophysical and optogenetic manipulation are allowing us to perturb the underlying machinery that generates these patterns in increasingly sophisticated ways. Rapid advances in theory and computing have made it possible to construct predictive models that describe how cell and tissue organization and dynamics emerge from the local coupling of biochemistry and mechanics. Together, these advances have opened up a wealth of new opportunities to explore how mechanochemical patterning shapes organismal development. In this roadmap, we present a series of forward-looking case studies on mechanochemical patterning in development, written by scientists working at the interface between the physical and biological sciences, and covering a wide range of spatial and temporal scales, organisms, and modes of development. Together, these contributions highlight the many ways in which the dynamic coupling of mechanics and biochemistry shapes biological dynamics: from mechanoenzymes that sense force to tune their activity and motor output, to collectives of cells in tissues that flow and redistribute biochemical signals during development.@eng' bibo_authorlist: - foaf_Person: foaf_givenName: Pierre François foaf_name: Lenne, Pierre François foaf_surname: Lenne - foaf_Person: foaf_givenName: Edwin foaf_name: Munro, Edwin foaf_surname: Munro - foaf_Person: foaf_givenName: Idse foaf_name: Heemskerk, Idse foaf_surname: Heemskerk - foaf_Person: foaf_givenName: Aryeh foaf_name: Warmflash, Aryeh foaf_surname: Warmflash - foaf_Person: foaf_givenName: Laura foaf_name: Bocanegra, Laura foaf_surname: Bocanegra foaf_workInfoHomepage: http://www.librecat.org/personId=4896F754-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Kasumi foaf_name: Kishi, Kasumi foaf_surname: Kishi foaf_workInfoHomepage: http://www.librecat.org/personId=3065DFC4-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Anna foaf_name: Kicheva, Anna foaf_surname: Kicheva foaf_workInfoHomepage: http://www.librecat.org/personId=3959A2A0-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0003-4509-4998 - foaf_Person: foaf_givenName: Yuchen foaf_name: Long, Yuchen foaf_surname: Long - foaf_Person: foaf_givenName: Antoine foaf_name: Fruleux, Antoine foaf_surname: Fruleux - foaf_Person: foaf_givenName: Arezki foaf_name: Boudaoud, Arezki foaf_surname: Boudaoud - foaf_Person: foaf_givenName: Timothy E. foaf_name: Saunders, Timothy E. foaf_surname: Saunders - foaf_Person: foaf_givenName: Paolo foaf_name: Caldarelli, Paolo foaf_surname: Caldarelli - foaf_Person: foaf_givenName: Arthur foaf_name: Michaut, Arthur foaf_surname: Michaut - foaf_Person: foaf_givenName: Jerome foaf_name: Gros, Jerome foaf_surname: Gros - foaf_Person: foaf_givenName: Yonit foaf_name: Maroudas-Sacks, Yonit foaf_surname: Maroudas-Sacks - foaf_Person: foaf_givenName: Kinneret foaf_name: Keren, Kinneret foaf_surname: Keren - foaf_Person: foaf_givenName: Edouard B foaf_name: Hannezo, Edouard B foaf_surname: Hannezo foaf_workInfoHomepage: http://www.librecat.org/personId=3A9DB764-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-6005-1561 - foaf_Person: foaf_givenName: Zev J. foaf_name: Gartner, Zev J. foaf_surname: Gartner - foaf_Person: foaf_givenName: Benjamin foaf_name: Stormo, Benjamin foaf_surname: Stormo - foaf_Person: foaf_givenName: Amy foaf_name: Gladfelter, Amy foaf_surname: Gladfelter - foaf_Person: foaf_givenName: Alan foaf_name: Rodrigues, Alan foaf_surname: Rodrigues - foaf_Person: foaf_givenName: Amy foaf_name: Shyer, Amy foaf_surname: Shyer - foaf_Person: foaf_givenName: Nicolas foaf_name: Minc, Nicolas foaf_surname: Minc - foaf_Person: foaf_givenName: Jean Léon foaf_name: Maître, Jean Léon foaf_surname: Maître - foaf_Person: foaf_givenName: Stefano foaf_name: Di Talia, Stefano foaf_surname: Di Talia - foaf_Person: foaf_givenName: Bassma foaf_name: Khamaisi, Bassma foaf_surname: Khamaisi - foaf_Person: foaf_givenName: David foaf_name: Sprinzak, David foaf_surname: Sprinzak - foaf_Person: foaf_givenName: Sham foaf_name: Tlili, Sham foaf_surname: Tlili bibo_doi: 10.1088/1478-3975/abd0db bibo_issue: '4' bibo_volume: 18 dct_date: 2021^xs_gYear dct_identifier: - UT:000640396400001 dct_isPartOf: - http://id.crossref.org/issn/1478-3975 dct_language: eng dct_publisher: IOP Publishing@ dct_title: Roadmap for the multiscale coupling of biochemical and mechanical signals during development@ fabio_hasPubmedId: '33276350' ...