---
res:
  bibo_abstract:
  - When B cells encounter membrane-bound antigens, the formation and coalescence
    of B cell antigen receptor (BCR) microclusters amplifies BCR signaling. The ability
    of B cells to probe the surface of antigen-presenting cells (APCs) and respond
    to APC-bound antigens requires remodeling of the actin cytoskeleton. Initial BCR
    signaling stimulates actin-related protein (Arp) 2/3 complex-dependent actin polymerization,
    which drives B cell spreading as well as the centripetal movement and coalescence
    of BCR microclusters at the B cell-APC synapse. Sustained actin polymerization
    depends on concomitant actin filament depolymerization, which enables the recycling
    of actin monomers and Arp2/3 complexes. Cofilin-mediated severing of actin filaments
    is a rate-limiting step in the morphological changes that occur during immune
    synapse formation. Hence, regulators of cofilin activity such as WD repeat-containing
    protein 1 (Wdr1), LIM domain kinase (LIMK), and coactosin-like 1 (Cotl1) may also
    be essential for actin-dependent processes in B cells. Wdr1 enhances cofilin-mediated
    actin disassembly. Conversely, Cotl1 competes with cofilin for binding to actin
    and LIMK phosphorylates cofilin and prevents it from binding to actin filaments.
    We now show that Wdr1 and LIMK have distinct roles in BCR-induced assembly of
    the peripheral actin structures that drive B cell spreading, and that cofilin,
    Wdr1, and LIMK all contribute to the actin-dependent amplification of BCR signaling
    at the immune synapse. Depleting Cotl1 had no effect on these processes. Thus,
    the Wdr1-LIMK-cofilin axis is critical for BCR-induced actin remodeling and for
    B cell responses to APC-bound antigens.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Madison
      foaf_name: Bolger-Munro, Madison
      foaf_surname: Bolger-Munro
      foaf_workInfoHomepage: http://www.librecat.org/personId=516F03FA-93A3-11EA-A7C5-D6BE3DDC885E
    orcid: 0000-0002-8176-4824
  - foaf_Person:
      foaf_givenName: Kate
      foaf_name: Choi, Kate
      foaf_surname: Choi
  - foaf_Person:
      foaf_givenName: Faith
      foaf_name: Cheung, Faith
      foaf_surname: Cheung
  - foaf_Person:
      foaf_givenName: Yi Tian
      foaf_name: Liu, Yi Tian
      foaf_surname: Liu
  - foaf_Person:
      foaf_givenName: May
      foaf_name: Dang-Lawson, May
      foaf_surname: Dang-Lawson
  - foaf_Person:
      foaf_givenName: Nikola
      foaf_name: Deretic, Nikola
      foaf_surname: Deretic
  - foaf_Person:
      foaf_givenName: Connor
      foaf_name: Keane, Connor
      foaf_surname: Keane
  - foaf_Person:
      foaf_givenName: Michael R.
      foaf_name: Gold, Michael R.
      foaf_surname: Gold
  bibo_doi: 10.3389/fcell.2021.649433
  bibo_volume: 9
  dct_date: 2021^xs_gYear
  dct_identifier:
  - UT:000644419500001
  dct_isPartOf:
  - http://id.crossref.org/issn/2296-634X
  dct_language: eng
  dct_publisher: Frontiers Media@
  dct_subject:
  - B cell
  - actin
  - immune synapse
  - cell spreading
  - cofilin
  - WDR1 (AIP1)
  - LIM domain kinase
  - B cell receptor (BCR)
  dct_title: The Wdr1-LIMK-Cofilin axis controls B cell antigen receptor-induced actin
    remodeling and signaling at the immune synapse@
  fabio_hasPubmedId: '33928084'
...