---
res:
  bibo_abstract:
  - Accumulation of interstitial fluid (IF) between embryonic cells is a common phenomenon
    in vertebrate embryogenesis. Unlike other model systems, where these accumulations
    coalesce into a large central cavity – the blastocoel, in zebrafish, IF is more
    uniformly distributed between the deep cells (DC) before the onset of gastrulation.
    This is likely due to the presence of a large extraembryonic structure – the yolk
    cell (YC) at the position where the blastocoel typically forms in other model
    organisms. IF has long been speculated to play a role in tissue morphogenesis
    during embryogenesis, but direct evidence supporting such function is still sparse.
    Here we show that the relocalization of IF to the interface between the YC and
    DC/epiblast is critical for axial mesendoderm (ME) cell protrusion formation and
    migration along this interface, a key process in embryonic axis formation. We
    further demonstrate that axial ME cell migration and IF relocalization engage
    in a positive feedback loop, where axial ME migration triggers IF accumulation
    ahead of the advancing axial ME tissue by mechanically compressing the overlying
    epiblast cell layer. Upon compression, locally induced flow relocalizes the IF
    through the porous epiblast tissue resulting in an IF accumulation ahead of the
    leading axial ME. This IF accumulation, in turn, promotes cell protrusion formation
    and migration of the leading axial ME cells, thereby facilitating axial ME extension.
    Our findings reveal a central role of dynamic IF relocalization in orchestrating
    germ layer morphogenesis during gastrulation.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Karla
      foaf_name: Huljev, Karla
      foaf_surname: Huljev
      foaf_workInfoHomepage: http://www.librecat.org/personId=44C6F6A6-F248-11E8-B48F-1D18A9856A87
  bibo_doi: 10.15479/at:ista:9397
  dct_date: 2021^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2663-337X
  dct_language: eng
  dct_publisher: Institute of Science and Technology Austria@
  dct_title: Coordinated spatiotemporal reorganization of interstitial fluid is required
    for axial mesendoderm migration in zebrafish gastrulation@
...