---
res:
  bibo_abstract:
  - De novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin3
    lead to autism spectrum disorder (ASD). In mouse, constitutive haploinsufficiency
    leads to motor coordination deficits as well as ASD-relevant social and cognitive
    impairments. However, induction of Cul3 haploinsufficiency later in life does
    not lead to ASD-relevant behaviors, pointing to an important role of Cul3 during
    a critical developmental window. Here we show that Cul3 is essential to regulate
    neuronal migration and, therefore, constitutive Cul3 heterozygous mutant mice
    display cortical lamination abnormalities. At the molecular level, we found that
    Cul3 controls neuronal migration by tightly regulating the amount of Plastin3
    (Pls3), a previously unrecognized player of neural migration. Furthermore, we
    found that Pls3 cell-autonomously regulates cell migration by regulating actin
    cytoskeleton organization, and its levels are inversely proportional to neural
    migration speed. Finally, we provide evidence that cellular phenotypes associated
    with autism-linked gene haploinsufficiency can be rescued by transcriptional activation
    of the intact allele in vitro, offering a proof of concept for a potential therapeutic
    approach for ASDs.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Jasmin
      foaf_name: Morandell, Jasmin
      foaf_surname: Morandell
      foaf_workInfoHomepage: http://www.librecat.org/personId=4739D480-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Lena A
      foaf_name: Schwarz, Lena A
      foaf_surname: Schwarz
      foaf_workInfoHomepage: http://www.librecat.org/personId=29A8453C-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Bernadette
      foaf_name: Basilico, Bernadette
      foaf_surname: Basilico
      foaf_workInfoHomepage: http://www.librecat.org/personId=36035796-5ACA-11E9-A75E-7AF2E5697425
    orcid: 0000-0003-1843-3173
  - foaf_Person:
      foaf_givenName: Saren
      foaf_name: Tasciyan, Saren
      foaf_surname: Tasciyan
      foaf_workInfoHomepage: http://www.librecat.org/personId=4323B49C-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-1671-393X
  - foaf_Person:
      foaf_givenName: Georgi A
      foaf_name: Dimchev, Georgi A
      foaf_surname: Dimchev
      foaf_workInfoHomepage: http://www.librecat.org/personId=38C393BE-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8370-6161
  - foaf_Person:
      foaf_givenName: Armel
      foaf_name: Nicolas, Armel
      foaf_surname: Nicolas
      foaf_workInfoHomepage: http://www.librecat.org/personId=2A103192-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Christoph M
      foaf_name: Sommer, Christoph M
      foaf_surname: Sommer
      foaf_workInfoHomepage: http://www.librecat.org/personId=4DF26D8C-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-1216-9105
  - foaf_Person:
      foaf_givenName: Caroline
      foaf_name: Kreuzinger, Caroline
      foaf_surname: Kreuzinger
      foaf_workInfoHomepage: http://www.librecat.org/personId=382077BA-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Christoph
      foaf_name: Dotter, Christoph
      foaf_surname: Dotter
      foaf_workInfoHomepage: http://www.librecat.org/personId=4C66542E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-9033-9096
  - foaf_Person:
      foaf_givenName: Lisa
      foaf_name: Knaus, Lisa
      foaf_surname: Knaus
      foaf_workInfoHomepage: http://www.librecat.org/personId=3B2ABCF4-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Zoe
      foaf_name: Dobler, Zoe
      foaf_surname: Dobler
      foaf_workInfoHomepage: http://www.librecat.org/personId=D23090A2-9057-11EA-883A-A8396FC7A38F
  - foaf_Person:
      foaf_givenName: Emanuele
      foaf_name: Cacci, Emanuele
      foaf_surname: Cacci
  - foaf_Person:
      foaf_givenName: Florian KM
      foaf_name: Schur, Florian KM
      foaf_surname: Schur
      foaf_workInfoHomepage: http://www.librecat.org/personId=48AD8942-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-4790-8078
  - foaf_Person:
      foaf_givenName: Johann G
      foaf_name: Danzl, Johann G
      foaf_surname: Danzl
      foaf_workInfoHomepage: http://www.librecat.org/personId=42EFD3B6-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8559-3973
  - foaf_Person:
      foaf_givenName: Gaia
      foaf_name: Novarino, Gaia
      foaf_surname: Novarino
      foaf_workInfoHomepage: http://www.librecat.org/personId=3E57A680-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-7673-7178
  bibo_doi: 10.1038/s41467-021-23123-x
  bibo_issue: '1'
  bibo_volume: 12
  dct_date: 2021^xs_gYear
  dct_identifier:
  - UT:000658769900010
  dct_isPartOf:
  - http://id.crossref.org/issn/2041-1723
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_subject:
  - General Biochemistry
  - Genetics and Molecular Biology
  dct_title: Cul3 regulates cytoskeleton protein homeostasis and cell migration during
    a critical window of brain development@
...