---
_id: '943'
abstract:
- lang: eng
  text: Like many developing tissues, the vertebrate neural tube is patterned by antiparallel
    morphogen gradients. To understand how these inputs are interpreted, we measured
    morphogen signaling and target gene expression in mouse embryos and chick ex vivo
    assays. From these data, we derived and validated a characteristic decoding map
    that relates morphogen input to the positional identity of neural progenitors.
    Analysis of the observed responses indicates that the underlying interpretation
    strategy minimizes patterning errors in response to the joint input of noisy opposing
    gradients. We reverse-engineered a transcriptional network that provides a mechanistic
    basis for the observed cell fate decisions and accounts for the precision and
    dynamics of pattern formation. Together, our data link opposing gradient dynamics
    in a growing tissue to precise pattern formation.
article_processing_charge: No
author:
- first_name: Marcin P
  full_name: Zagórski, Marcin P
  id: 343DA0DC-F248-11E8-B48F-1D18A9856A87
  last_name: Zagórski
  orcid: 0000-0001-7896-7762
- first_name: Yoji
  full_name: Tabata, Yoji
  last_name: Tabata
- first_name: Nathalie
  full_name: Brandenberg, Nathalie
  last_name: Brandenberg
- first_name: Matthias
  full_name: Lutolf, Matthias
  last_name: Lutolf
- first_name: Gasper
  full_name: Tkacik, Gasper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
- first_name: Tobias
  full_name: Bollenbach, Tobias
  last_name: Bollenbach
- first_name: James
  full_name: Briscoe, James
  last_name: Briscoe
- first_name: Anna
  full_name: Kicheva, Anna
  id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
  last_name: Kicheva
  orcid: 0000-0003-4509-4998
citation:
  ama: Zagórski MP, Tabata Y, Brandenberg N, et al. Decoding of position in the developing
    neural tube from antiparallel morphogen gradients. <i>Science</i>. 2017;356(6345):1379-1383.
    doi:<a href="https://doi.org/10.1126/science.aam5887">10.1126/science.aam5887</a>
  apa: Zagórski, M. P., Tabata, Y., Brandenberg, N., Lutolf, M., Tkačik, G., Bollenbach,
    T., … Kicheva, A. (2017). Decoding of position in the developing neural tube from
    antiparallel morphogen gradients. <i>Science</i>. American Association for the
    Advancement of Science. <a href="https://doi.org/10.1126/science.aam5887">https://doi.org/10.1126/science.aam5887</a>
  chicago: Zagórski, Marcin P, Yoji Tabata, Nathalie Brandenberg, Matthias Lutolf,
    Gašper Tkačik, Tobias Bollenbach, James Briscoe, and Anna Kicheva. “Decoding of
    Position in the Developing Neural Tube from Antiparallel Morphogen Gradients.”
    <i>Science</i>. American Association for the Advancement of Science, 2017. <a
    href="https://doi.org/10.1126/science.aam5887">https://doi.org/10.1126/science.aam5887</a>.
  ieee: M. P. Zagórski <i>et al.</i>, “Decoding of position in the developing neural
    tube from antiparallel morphogen gradients,” <i>Science</i>, vol. 356, no. 6345.
    American Association for the Advancement of Science, pp. 1379–1383, 2017.
  ista: Zagórski MP, Tabata Y, Brandenberg N, Lutolf M, Tkačik G, Bollenbach T, Briscoe
    J, Kicheva A. 2017. Decoding of position in the developing neural tube from antiparallel
    morphogen gradients. Science. 356(6345), 1379–1383.
  mla: Zagórski, Marcin P., et al. “Decoding of Position in the Developing Neural
    Tube from Antiparallel Morphogen Gradients.” <i>Science</i>, vol. 356, no. 6345,
    American Association for the Advancement of Science, 2017, pp. 1379–83, doi:<a
    href="https://doi.org/10.1126/science.aam5887">10.1126/science.aam5887</a>.
  short: M.P. Zagórski, Y. Tabata, N. Brandenberg, M. Lutolf, G. Tkačik, T. Bollenbach,
    J. Briscoe, A. Kicheva, Science 356 (2017) 1379–1383.
corr_author: '1'
date_created: 2018-12-11T11:49:20Z
date_published: 2017-06-30T00:00:00Z
date_updated: 2025-07-10T12:01:45Z
day: '30'
department:
- _id: AnKi
- _id: GaTk
doi: 10.1126/science.aam5887
ec_funded: 1
external_id:
  isi:
  - '000404351500036'
  pmid:
  - '28663499'
fulldoi: https://doi.org/10.1126/science.aam5887
intvolume: '       356'
isi: 1
issue: '6345'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568706/
month: '06'
oa: 1
oa_version: Submitted Version
page: 1379 - 1383
pmid: 1
project:
- _id: 254E9036-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P28844-B27
  name: Biophysics of information processing in gene regulation
- _id: B6FC0238-B512-11E9-945C-1524E6697425
  call_identifier: H2020
  grant_number: '680037'
  name: Coordination of Patterning And Growth In the Spinal Cord
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
- _id: 2524F500-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '201439'
  name: Developing High-Throughput Bioassays for Human Cancers in Zebrafish
publication: Science
publication_identifier:
  issn:
  - 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '6474'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Decoding of position in the developing neural tube from antiparallel morphogen
  gradients
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 356
year: '2017'
...