---
_id: '9455'
abstract:
- lang: eng
  text: Proteins of the ARGONAUTE family are important in diverse posttranscriptional
    RNA-mediated gene-silencing systems as well as in transcriptional gene silencing
    in Drosophila and fission yeast and in programmed DNA elimination in Tetrahymena.
    We cloned ARGONAUTE4 (AGO4) from a screen for mutants that suppress silencing
    of the Arabidopsis SUPERMAN(SUP) gene. The ago4-1 mutant reactivated silentSUP
    alleles and decreased CpNpG and asymmetric DNA methylation as well as histone
    H3 lysine-9 methylation. In addition,ago4-1 blocked histone and DNA methylation
    and the accumulation of 25-nucleotide small interfering RNAs (siRNAs) that correspond
    to the retroelement AtSN1. These results suggest that AGO4 and long siRNAs direct
    chromatin modifications, including histone methylation and non-CpG DNA methylation.
article_processing_charge: No
article_type: original
author:
- first_name: Daniel
  full_name: Zilberman, Daniel
  id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
  last_name: Zilberman
  orcid: 0000-0002-0123-8649
- first_name: ' Xiaofeng'
  full_name: Cao,  Xiaofeng
  last_name: Cao
- first_name: Steven E.
  full_name: Jacobsen, Steven E.
  last_name: Jacobsen
citation:
  ama: Zilberman D, Cao  Xiaofeng, Jacobsen SE. ARGONAUTE4 control of locus-specific
    siRNA accumulation and DNA and histone methylation. <i>Science</i>. 2003;299(5607):716-719.
    doi:<a href="https://doi.org/10.1126/science.1079695">10.1126/science.1079695</a>
  apa: Zilberman, D., Cao,  Xiaofeng, &#38; Jacobsen, S. E. (2003). ARGONAUTE4 control
    of locus-specific siRNA accumulation and DNA and histone methylation. <i>Science</i>.
    American Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.1079695">https://doi.org/10.1126/science.1079695</a>
  chicago: Zilberman, Daniel,  Xiaofeng Cao, and Steven E. Jacobsen. “ARGONAUTE4 Control
    of Locus-Specific SiRNA Accumulation and DNA and Histone Methylation.” <i>Science</i>.
    American Association for the Advancement of Science, 2003. <a href="https://doi.org/10.1126/science.1079695">https://doi.org/10.1126/science.1079695</a>.
  ieee: D. Zilberman,  Xiaofeng Cao, and S. E. Jacobsen, “ARGONAUTE4 control of locus-specific
    siRNA accumulation and DNA and histone methylation,” <i>Science</i>, vol. 299,
    no. 5607. American Association for the Advancement of Science, pp. 716–719, 2003.
  ista: Zilberman D, Cao  Xiaofeng, Jacobsen SE. 2003. ARGONAUTE4 control of locus-specific
    siRNA accumulation and DNA and histone methylation. Science. 299(5607), 716–719.
  mla: Zilberman, Daniel, et al. “ARGONAUTE4 Control of Locus-Specific SiRNA Accumulation
    and DNA and Histone Methylation.” <i>Science</i>, vol. 299, no. 5607, American
    Association for the Advancement of Science, 2003, pp. 716–19, doi:<a href="https://doi.org/10.1126/science.1079695">10.1126/science.1079695</a>.
  short: D. Zilberman,  Xiaofeng Cao, S.E. Jacobsen, Science 299 (2003) 716–719.
date_created: 2021-06-04T11:26:26Z
date_published: 2003-01-31T00:00:00Z
date_updated: 2021-12-14T08:43:30Z
day: '31'
department:
- _id: DaZi
doi: 10.1126/science.1079695
extern: '1'
external_id:
  pmid:
  - '12522258'
intvolume: '       299'
issue: '5607'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '01'
oa_version: None
page: 716-719
pmid: 1
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone
  methylation
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 299
year: '2003'
...