---
_id: '9505'
abstract:
- lang: eng
text: 'Cytosine methylation, a common form of DNA modification that antagonizes
transcription, is found at transposons and repeats in vertebrates, plants and
fungi. Here we have mapped DNA methylation in the entire Arabidopsis thaliana
genome at high resolution. DNA methylation covers transposons and is present within
a large fraction of A. thaliana genes. Methylation within genes is conspicuously
biased away from gene ends, suggesting a dependence on RNA polymerase transit.
Genic methylation is strongly influenced by transcription: moderately transcribed
genes are most likely to be methylated, whereas genes at either extreme are least
likely. In turn, transcription is influenced by methylation: short methylated
genes are poorly expressed, and loss of methylation in the body of a gene leads
to enhanced transcription. Our results indicate that genic transcription and DNA
methylation are closely interwoven processes.'
article_processing_charge: No
article_type: original
author:
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
- first_name: Mary
full_name: Gehring, Mary
last_name: Gehring
- first_name: Robert K.
full_name: Tran, Robert K.
last_name: Tran
- first_name: Tracy
full_name: Ballinger, Tracy
last_name: Ballinger
- first_name: Steven
full_name: Henikoff, Steven
last_name: Henikoff
citation:
ama: Zilberman D, Gehring M, Tran RK, Ballinger T, Henikoff S. Genome-wide analysis
of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation
and transcription. Nature Genetics. 2006;39(1):61-69. doi:10.1038/ng1929
apa: Zilberman, D., Gehring, M., Tran, R. K., Ballinger, T., & Henikoff, S.
(2006). Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers
an interdependence between methylation and transcription. Nature Genetics.
Nature Publishing Group. https://doi.org/10.1038/ng1929
chicago: Zilberman, Daniel, Mary Gehring, Robert K. Tran, Tracy Ballinger, and Steven
Henikoff. “Genome-Wide Analysis of Arabidopsis Thaliana DNA Methylation Uncovers
an Interdependence between Methylation and Transcription.” Nature Genetics.
Nature Publishing Group, 2006. https://doi.org/10.1038/ng1929.
ieee: D. Zilberman, M. Gehring, R. K. Tran, T. Ballinger, and S. Henikoff, “Genome-wide
analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between
methylation and transcription,” Nature Genetics, vol. 39, no. 1. Nature
Publishing Group, pp. 61–69, 2006.
ista: Zilberman D, Gehring M, Tran RK, Ballinger T, Henikoff S. 2006. Genome-wide
analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between
methylation and transcription. Nature Genetics. 39(1), 61–69.
mla: Zilberman, Daniel, et al. “Genome-Wide Analysis of Arabidopsis Thaliana DNA
Methylation Uncovers an Interdependence between Methylation and Transcription.”
Nature Genetics, vol. 39, no. 1, Nature Publishing Group, 2006, pp. 61–69,
doi:10.1038/ng1929.
short: D. Zilberman, M. Gehring, R.K. Tran, T. Ballinger, S. Henikoff, Nature Genetics
39 (2006) 61–69.
date_created: 2021-06-07T12:19:31Z
date_published: 2006-11-26T00:00:00Z
date_updated: 2021-12-14T09:02:51Z
day: '26'
department:
- _id: DaZi
doi: 10.1038/ng1929
extern: '1'
external_id:
pmid:
- '17128275'
intvolume: ' 39'
issue: '1'
language:
- iso: eng
month: '11'
oa_version: None
page: 61-69
pmid: 1
publication: Nature Genetics
publication_identifier:
eissn:
- 1546-1718
issn:
- 1061-4036
publication_status: published
publisher: Nature Publishing Group
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence
between methylation and transcription
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 39
year: '2006'
...