---
res:
  bibo_abstract:
  - "Background:\r\nDNA methylation occurs at preferred sites in eukaryotes. In Arabidopsis,
    DNA cytosine methylation is maintained by three subfamilies of methyltransferases
    with distinct substrate specificities and different modes of action. Targeting
    of cytosine methylation at selected loci has been found to sometimes involve histone
    H3 methylation and small interfering (si)RNAs. However, the relationship between
    different cytosine methylation pathways and their preferred targets is not known.\r\nResults:\r\nWe
    used a microarray-based profiling method to explore the involvement of Arabidopsis
    CMT3 and DRM DNA methyltransferases, a histone H3 lysine-9 methyltransferase (KYP)
    and an Argonaute-related siRNA silencing component (AGO4) in methylating target
    loci. We found that KYP targets are also CMT3 targets, suggesting that histone
    methylation maintains CNG methylation genome-wide. CMT3 and KYP targets show similar
    proximal distributions that correspond to the overall distribution of transposable
    elements of all types, whereas DRM targets are distributed more distally along
    the chromosome. We find an inverse relationship between element size and loss
    of methylation in ago4 and drm mutants.\r\nConclusion:\r\nWe conclude that the
    targets of both DNA methylation and histone H3K9 methylation pathways are transposable
    elements genome-wide, irrespective of element type and position. Our findings
    also suggest that RNA-directed DNA methylation is required to silence isolated
    elements that may be too small to be maintained in a silent state by a chromatin-based
    mechanism alone. Thus, parallel pathways would be needed to maintain silencing
    of transposable elements.@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Robert K.
      foaf_name: Tran, Robert K.
      foaf_surname: Tran
  - foaf_Person:
      foaf_givenName: Daniel
      foaf_name: Zilberman, Daniel
      foaf_surname: Zilberman
      foaf_workInfoHomepage: http://www.librecat.org/personId=6973db13-dd5f-11ea-814e-b3e5455e9ed1
    orcid: 0000-0002-0123-8649
  - foaf_Person:
      foaf_givenName: Cecilia
      foaf_name: de Bustos, Cecilia
      foaf_surname: de Bustos
  - foaf_Person:
      foaf_givenName: Renata F.
      foaf_name: Ditt, Renata F.
      foaf_surname: Ditt
  - foaf_Person:
      foaf_givenName: Jorja G.
      foaf_name: Henikoff, Jorja G.
      foaf_surname: Henikoff
  - foaf_Person:
      foaf_givenName: Anders M.
      foaf_name: Lindroth, Anders M.
      foaf_surname: Lindroth
  - foaf_Person:
      foaf_givenName: Jeffrey
      foaf_name: Delrow, Jeffrey
      foaf_surname: Delrow
  - foaf_Person:
      foaf_givenName: Tom
      foaf_name: Boyle, Tom
      foaf_surname: Boyle
  - foaf_Person:
      foaf_givenName: Samson
      foaf_name: Kwong, Samson
      foaf_surname: Kwong
  - foaf_Person:
      foaf_givenName: Terri D.
      foaf_name: Bryson, Terri D.
      foaf_surname: Bryson
  - foaf_Person:
      foaf_givenName: Steven E.
      foaf_name: Jacobsen, Steven E.
      foaf_surname: Jacobsen
  - foaf_Person:
      foaf_givenName: Steven
      foaf_name: Henikoff, Steven
      foaf_surname: Henikoff
  bibo_doi: 10.1186/gb-2005-6-11-r90
  bibo_issue: '11'
  bibo_volume: 6
  dct_date: 2005^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1474-760X
  - http://id.crossref.org/issn/1465-6906
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Chromatin and siRNA pathways cooperate to maintain DNA methylation of
    small transposable elements in Arabidopsis@
  fabio_hasPubmedId: '16277745'
...