article published yes Daniel Zilberman author 6973db13-dd5f-11ea-814e-b3e5455e9ed10000-0002-0123-8649 DaZi department DNA methylation is an ancient process found in all domains of life. Although the enzymes that mediate methylation have remained highly conserved, DNA methylation has been adapted for a variety of uses throughout evolution, including defense against transposable elements and control of gene expression. Defects in DNA methylation are linked to human diseases, including cancer. Methylation has been lost several times in the course of animal and fungal evolution, thus limiting the opportunity for study in common model organisms. In the past decade, plants have emerged as a premier model system for genetic dissection of DNA methylation. A recent combination of plant genetics with powerful genomic approaches has led to a number of exciting discoveries and promises many more. Elsevier 2008 eng 1369-5266 1877433110.1016/j.pbi.2008.07.004 115554-559 yes Zilberman D. The evolving functions of DNA methylation. <i>Current Opinion in Plant Biology</i>. 2008;11(5):554-559. doi:<a href="https://doi.org/10.1016/j.pbi.2008.07.004">10.1016/j.pbi.2008.07.004</a> Zilberman D. 2008. The evolving functions of DNA methylation. Current Opinion in Plant Biology. 11(5), 554–559. Zilberman, Daniel. “The Evolving Functions of DNA Methylation.” <i>Current Opinion in Plant Biology</i>. Elsevier , 2008. <a href="https://doi.org/10.1016/j.pbi.2008.07.004">https://doi.org/10.1016/j.pbi.2008.07.004</a>. D. Zilberman, Current Opinion in Plant Biology 11 (2008) 554–559. D. Zilberman, “The evolving functions of DNA methylation,” <i>Current Opinion in Plant Biology</i>, vol. 11, no. 5. Elsevier , pp. 554–559, 2008. Zilberman, Daniel. “The Evolving Functions of DNA Methylation.” <i>Current Opinion in Plant Biology</i>, vol. 11, no. 5, Elsevier , 2008, pp. 554–59, doi:<a href="https://doi.org/10.1016/j.pbi.2008.07.004">10.1016/j.pbi.2008.07.004</a>. Zilberman, D. (2008). The evolving functions of DNA methylation. <i>Current Opinion in Plant Biology</i>. Elsevier . <a href="https://doi.org/10.1016/j.pbi.2008.07.004">https://doi.org/10.1016/j.pbi.2008.07.004</a> 95372021-06-08T13:13:37Z2021-12-14T08:54:07Z