---
res:
  bibo_abstract:
  - AMPA receptors (AMPARs) mediate the majority of excitatory transmission in the
    brain and enable the synaptic plasticity that underlies learning1. A diverse array
    of AMPAR signalling complexes are established by receptor auxiliary subunits,
    which associate with the AMPAR in various combinations to modulate trafficking,
    gating and synaptic strength2. However, their mechanisms of action are poorly
    understood. Here we determine cryo-electron microscopy structures of the heteromeric
    GluA1–GluA2 receptor assembled with both TARP-γ8 and CNIH2, the predominant AMPAR
    complex in the forebrain, in both resting and active states. Two TARP-γ8 and two
    CNIH2 subunits insert at distinct sites beneath the ligand-binding domains of
    the receptor, with site-specific lipids shaping each interaction and affecting
    the gating regulation of the AMPARs. Activation of the receptor leads to asymmetry
    between GluA1 and GluA2 along the ion conduction path and an outward expansion
    of the channel triggers counter-rotations of both auxiliary subunit pairs, promoting
    the active-state conformation. In addition, both TARP-γ8 and CNIH2 pivot towards
    the pore exit upon activation, extending their reach for cytoplasmic receptor
    elements. CNIH2 achieves this through its uniquely extended M2 helix, which has
    transformed this endoplasmic reticulum-export factor into a powerful AMPAR modulator
    that is capable of providing hippocampal pyramidal neurons with their integrative
    synaptic properties. @eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Danyang
      foaf_name: Zhang, Danyang
      foaf_surname: Zhang
  - foaf_Person:
      foaf_givenName: Jake
      foaf_name: Watson, Jake
      foaf_surname: Watson
      foaf_workInfoHomepage: http://www.librecat.org/personId=63836096-4690-11EA-BD4E-32803DDC885E
    orcid: 0000-0002-8698-3823
  - foaf_Person:
      foaf_givenName: Peter M.
      foaf_name: Matthews, Peter M.
      foaf_surname: Matthews
  - foaf_Person:
      foaf_givenName: Ondrej
      foaf_name: Cais, Ondrej
      foaf_surname: Cais
  - foaf_Person:
      foaf_givenName: Ingo H.
      foaf_name: Greger, Ingo H.
      foaf_surname: Greger
  bibo_doi: 10.1038/s41586-021-03613-0
  bibo_volume: 594
  dct_date: 2021^xs_gYear
  dct_identifier:
  - UT:000657238100003
  dct_isPartOf:
  - http://id.crossref.org/issn/0028-0836
  - http://id.crossref.org/issn/1476-4687
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Gating and modulation of a hetero-octameric AMPA glutamate receptor@
  fabio_hasPubmedId: '34079129'
...