---
res:
  bibo_abstract:
  - 'In mammalian genomes, differentially methylated regions (DMRs) and histone marks
    including trimethylation of histone 3 lysine 27 (H3K27me3) at imprinted genes
    are asymmetrically inherited to control parentally-biased gene expression. However,
    neither parent-of-origin-specific transcription nor imprints have been comprehensively
    mapped at the blastocyst stage of preimplantation development. Here, we address
    this by integrating transcriptomic and epigenomic approaches in mouse preimplantation
    embryos. We find that seventy-one genes exhibit previously unreported parent-of-origin-specific
    expression in blastocysts (nBiX: novel blastocyst-imprinted expressed). Uniparental
    expression of nBiX genes disappears soon after implantation. Micro-whole-genome
    bisulfite sequencing (µWGBS) of individual uniparental blastocysts detects 859
    DMRs. We further find that 16% of nBiX genes are associated with a DMR, whereas
    most are associated with parentally-biased H3K27me3, suggesting a role for Polycomb-mediated
    imprinting in blastocysts. nBiX genes are clustered: five clusters contained at
    least one published imprinted gene, and five clusters exclusively contained nBiX
    genes. These data suggest that early development undergoes a complex program of
    stage-specific imprinting involving different tiers of regulation.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Laura
      foaf_name: Santini, Laura
      foaf_surname: Santini
  - foaf_Person:
      foaf_givenName: Florian
      foaf_name: Halbritter, Florian
      foaf_surname: Halbritter
  - foaf_Person:
      foaf_givenName: Fabian
      foaf_name: Titz-Teixeira, Fabian
      foaf_surname: Titz-Teixeira
  - foaf_Person:
      foaf_givenName: Toru
      foaf_name: Suzuki, Toru
      foaf_surname: Suzuki
  - foaf_Person:
      foaf_givenName: Maki
      foaf_name: Asami, Maki
      foaf_surname: Asami
  - foaf_Person:
      foaf_givenName: Xiaoyan
      foaf_name: Ma, Xiaoyan
      foaf_surname: Ma
  - foaf_Person:
      foaf_givenName: Julia
      foaf_name: Ramesmayer, Julia
      foaf_surname: Ramesmayer
  - foaf_Person:
      foaf_givenName: Andreas
      foaf_name: Lackner, Andreas
      foaf_surname: Lackner
  - foaf_Person:
      foaf_givenName: Nick
      foaf_name: Warr, Nick
      foaf_surname: Warr
  - foaf_Person:
      foaf_givenName: Florian
      foaf_name: Pauler, Florian
      foaf_surname: Pauler
      foaf_workInfoHomepage: http://www.librecat.org/personId=48EA0138-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-7462-0048
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Hippenmeyer, Simon
      foaf_surname: Hippenmeyer
      foaf_workInfoHomepage: http://www.librecat.org/personId=37B36620-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2279-1061
  - foaf_Person:
      foaf_givenName: Ernest
      foaf_name: Laue, Ernest
      foaf_surname: Laue
  - foaf_Person:
      foaf_givenName: Matthias
      foaf_name: Farlik, Matthias
      foaf_surname: Farlik
  - foaf_Person:
      foaf_givenName: Christoph
      foaf_name: Bock, Christoph
      foaf_surname: Bock
  - foaf_Person:
      foaf_givenName: Andreas
      foaf_name: Beyer, Andreas
      foaf_surname: Beyer
  - foaf_Person:
      foaf_givenName: Anthony C.F.
      foaf_name: Perry, Anthony C.F.
      foaf_surname: Perry
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Leeb, Martin
      foaf_surname: Leeb
  bibo_doi: 10.1038/s41467-021-23510-4
  bibo_issue: '1'
  bibo_volume: 12
  dct_date: 2021^xs_gYear
  dct_identifier:
  - UT:000667248600005
  dct_isPartOf:
  - http://id.crossref.org/issn/2041-1723
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Genomic imprinting in mouse blastocysts is predominantly associated with
    H3K27me3@
...