---
res:
  bibo_abstract:
  - Cell-cell  contact  formation  constitutes  the  first  step  in  the  emergence  of  multicellularity  in
    evolution, thereby  allowing  the  differentiation  of  specialized  cell  types.  In  metazoan
    development, cell-cell contact formation is thought to influence cell fate specification,
    and cell   fate   specification   has   been   implicated   in   cell-cell  contact
    formation.   However, remarkably little is yet known about whether and how the
    interaction and feedback between cell-cell contact formation and cell fate specification
    affect development. Here we identify a positive  feedback  loop  between  cell-cell  contact  duration,  morphogen  signaling  and
    mesendoderm  cell  fate  specification  during  zebrafish  gastrulation.  We  show  that  long
    lasting cell-cell contacts enhance the competence of prechordal plate (ppl) progenitor
    cells to  respond  to  Nodal  signaling,  required  for  proper  ppl  cell  fate  specification.  We  further
    show  that  Nodal  signalling  romotes  ppl  cell-cell  contact  duration,  thereby  generating  an
    effective  positive  feedback  loop  between  ppl  cell-cell  contact  duration  and  cell  fate
    specification. Finally, by using a combination of theoretical modeling and experimentation,
    we  show  that  this  feedback  loop  determines  whether  anterior  axial  mesendoderm  cells
    become  ppl  progenitors  or,  instead,  turn  into  endoderm  progenitors.  Our  findings  reveal
    that  the  gene  regulatory  networks  leading  to  cell  fate  diversification  within  the  developing
    embryo  are  controlled  by  the  interdependent  activities  of  cell-cell  signaling  and  contact
    formation.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Vanessa
      foaf_name: Barone, Vanessa
      foaf_surname: Barone
      foaf_workInfoHomepage: http://www.librecat.org/personId=419EECCC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2676-3367
  bibo_doi: 10.15479/AT:ISTA:th_825
  dct_date: 2017^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2663-337X
  dct_language: eng
  dct_publisher: Institute of Science and Technology Austria@
  dct_title: 'Cell adhesion and cell fate: An effective feedback loop during zebrafish
    gastrulation@'
...