--- res: bibo_abstract: - 'Selection and random drift determine the probability that novel mutations fixate in a population. Population structure is known to affect the dynamics of the evolutionary process. Amplifiers of selection are population structures that increase the fixation probability of beneficial mutants compared to well-mixed populations. Over the past 15 years, extensive research has produced remarkable structures called strong amplifiers which guarantee that every beneficial mutation fixates with high probability. But strong amplification has come at the cost of considerably delaying the fixation event, which can slow down the overall rate of evolution. However, the precise relationship between fixation probability and time has remained elusive. Here we characterize the slowdown effect of strong amplification. First, we prove that all strong amplifiers must delay the fixation event at least to some extent. Second, we construct strong amplifiers that delay the fixation event only marginally as compared to the well-mixed populations. Our results thus establish a tight relationship between fixation probability and time: Strong amplification always comes at a cost of a slowdown, but more than a marginal slowdown is not needed.@eng' bibo_authorlist: - foaf_Person: foaf_givenName: Josef foaf_name: Tkadlec, Josef foaf_surname: Tkadlec foaf_workInfoHomepage: http://www.librecat.org/personId=3F24CCC8-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-1097-9684 - foaf_Person: foaf_givenName: Andreas foaf_name: Pavlogiannis, Andreas foaf_surname: Pavlogiannis foaf_workInfoHomepage: http://www.librecat.org/personId=49704004-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8943-0722 - foaf_Person: foaf_givenName: Krishnendu foaf_name: Chatterjee, Krishnendu foaf_surname: Chatterjee foaf_workInfoHomepage: http://www.librecat.org/personId=2E5DCA20-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-4561-241X - foaf_Person: foaf_givenName: Martin A. foaf_name: Nowak, Martin A. foaf_surname: Nowak bibo_doi: 10.1038/s41467-021-24271-w bibo_issue: '1' bibo_volume: 12 dct_date: 2021^xs_gYear dct_identifier: - UT:000671752100003 dct_isPartOf: - http://id.crossref.org/issn/20411723 dct_language: eng dct_publisher: Springer Nature@ dct_title: Fast and strong amplifiers of natural selection@ fabio_hasPubmedId: '34188036' ...