--- res: bibo_abstract: - Perineuronal nets (PNNs), components of the extracellular matrix, preferentially coat parvalbumin-positive interneurons and constrain critical-period plasticity in the adult cerebral cortex. Current strategies to remove PNN are long-lasting, invasive, and trigger neuropsychiatric symptoms. Here, we apply repeated anesthetic ketamine as a method with minimal behavioral effect. We find that this paradigm strongly reduces PNN coating in the healthy adult brain and promotes juvenile-like plasticity. Microglia are critically involved in PNN loss because they engage with parvalbumin-positive neurons in their defined cortical layer. We identify external 60-Hz light-flickering entrainment to recapitulate microglia-mediated PNN removal. Importantly, 40-Hz frequency, which is known to remove amyloid plaques, does not induce PNN loss, suggesting microglia might functionally tune to distinct brain frequencies. Thus, our 60-Hz light-entrainment strategy provides an alternative form of PNN intervention in the healthy adult brain.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Alessandro foaf_name: Venturino, Alessandro foaf_surname: Venturino foaf_workInfoHomepage: http://www.librecat.org/personId=41CB84B2-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0003-2356-9403 - foaf_Person: foaf_givenName: Rouven foaf_name: Schulz, Rouven foaf_surname: Schulz foaf_workInfoHomepage: http://www.librecat.org/personId=4C5E7B96-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-5297-733X - foaf_Person: foaf_givenName: Héctor foaf_name: De Jesús-Cortés, Héctor foaf_surname: De Jesús-Cortés - foaf_Person: foaf_givenName: Margaret E foaf_name: Maes, Margaret E foaf_surname: Maes foaf_workInfoHomepage: http://www.librecat.org/personId=3838F452-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-9642-1085 - foaf_Person: foaf_givenName: Balint foaf_name: Nagy, Balint foaf_surname: Nagy foaf_workInfoHomepage: http://www.librecat.org/personId=93C65ECC-A6F2-11E9-8DF9-9712E6697425 - foaf_Person: foaf_givenName: Francis foaf_name: Reilly-Andújar, Francis foaf_surname: Reilly-Andújar - foaf_Person: foaf_givenName: Gloria foaf_name: Colombo, Gloria foaf_surname: Colombo foaf_workInfoHomepage: http://www.librecat.org/personId=3483CF6C-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-9434-8902 - foaf_Person: foaf_givenName: Ryan J foaf_name: Cubero, Ryan J foaf_surname: Cubero foaf_workInfoHomepage: http://www.librecat.org/personId=850B2E12-9CD4-11E9-837F-E719E6697425 orcid: 0000-0003-0002-1867 - foaf_Person: foaf_givenName: Florianne E foaf_name: Schoot Uiterkamp, Florianne E foaf_surname: Schoot Uiterkamp foaf_workInfoHomepage: http://www.librecat.org/personId=3526230C-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Mark F. foaf_name: Bear, Mark F. foaf_surname: Bear - foaf_Person: foaf_givenName: Sandra foaf_name: Siegert, Sandra foaf_surname: Siegert foaf_workInfoHomepage: http://www.librecat.org/personId=36ACD32E-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-8635-0877 bibo_doi: 10.1016/j.celrep.2021.109313 bibo_issue: '1' bibo_volume: 36 dct_date: 2021^xs_gYear dct_identifier: - UT:000670188500004 dct_isPartOf: - http://id.crossref.org/issn/22111247 dct_language: eng dct_publisher: Elsevier@ dct_title: Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain@ fabio_hasPubmedId: '34233180' ...