--- res: bibo_abstract: - The hippocampal mossy fiber synapse is a key synapse of the trisynaptic circuit. Post-tetanic potentiation (PTP) is the most powerful form of plasticity at this synaptic connection. It is widely believed that mossy fiber PTP is an entirely presynaptic phenomenon, implying that PTP induction is input-specific, and requires neither activity of multiple inputs nor stimulation of postsynaptic neurons. To directly test cooperativity and associativity, we made paired recordings between single mossy fiber terminals and postsynaptic CA3 pyramidal neurons in rat brain slices. By stimulating non-overlapping mossy fiber inputs converging onto single CA3 neurons, we confirm that PTP is input-specific and non-cooperative. Unexpectedly, mossy fiber PTP exhibits anti-associative induction properties. EPSCs show only minimal PTP after combined pre- and postsynaptic high-frequency stimulation with intact postsynaptic Ca2+ signaling, but marked PTP in the absence of postsynaptic spiking and after suppression of postsynaptic Ca2+ signaling (10 mM EGTA). PTP is largely recovered by inhibitors of voltage-gated R- and L-type Ca2+ channels, group II mGluRs, and vacuolar-type H+-ATPase, suggesting the involvement of retrograde vesicular glutamate signaling. Transsynaptic regulation of PTP extends the repertoire of synaptic computations, implementing a brake on mossy fiber detonation and a “smart teacher” function of hippocampal mossy fiber synapses.@eng bibo_authorlist: - foaf_Person: foaf_givenName: David H foaf_name: Vandael, David H foaf_surname: Vandael foaf_workInfoHomepage: http://www.librecat.org/personId=3AE48E0A-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-7577-1676 - foaf_Person: foaf_givenName: Yuji foaf_name: Okamoto, Yuji foaf_surname: Okamoto foaf_workInfoHomepage: http://www.librecat.org/personId=3337E116-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0003-0408-6094 - foaf_Person: foaf_givenName: Peter M foaf_name: Jonas, Peter M foaf_surname: Jonas foaf_workInfoHomepage: http://www.librecat.org/personId=353C1B58-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-5001-4804 bibo_doi: 10.1038/s41467-021-23153-5 bibo_issue: '1' bibo_volume: 12 dct_date: 2021^xs_gYear dct_identifier: - UT:000655481800014 dct_isPartOf: - http://id.crossref.org/issn/2041-1723 dct_language: eng dct_publisher: Springer@ dct_subject: - general physics and astronomy - general biochemistry - genetics and molecular biology - general chemistry dct_title: Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses@ ...