---
_id: '9838'
abstract:
- lang: eng
  text: 'Facial shape is the basis for facial recognition and categorization. Facial
    features reflect the underlying geometry of the skeletal structures. Here we reveal
    that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped
    by signals generated by neural structures: brain and olfactory epithelium. Brain-derived
    Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior nasal
    capsule, whereas the formation of a capsule roof is controlled by signals from
    the olfactory epithelium. Unexpectedly, the cartilage of the nasal capsule turned
    out to be important for shaping membranous facial bones during development. This
    suggests that conserved neurosensory structures could benefit from protection
    and have evolved signals inducing cranial cartilages encasing them. Experiments
    with mutant mice revealed that the genomic regulatory regions controlling production
    of SHH in the nervous system contribute to facial cartilage morphogenesis, which
    might be a mechanism responsible for the adaptive evolution of animal faces and
    snouts.'
article_processing_charge: No
author:
- first_name: Marketa
  full_name: Kaucka, Marketa
  last_name: Kaucka
- first_name: Julian
  full_name: Petersen, Julian
  last_name: Petersen
- first_name: Marketa
  full_name: Tesarova, Marketa
  last_name: Tesarova
- first_name: Bara
  full_name: Szarowska, Bara
  last_name: Szarowska
- first_name: Maria Eleni
  full_name: Kastriti, Maria Eleni
  last_name: Kastriti
- first_name: Meng
  full_name: Xie, Meng
  last_name: Xie
- first_name: Anna
  full_name: Kicheva, Anna
  id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
  last_name: Kicheva
  orcid: 0000-0003-4509-4998
- first_name: Karl
  full_name: Annusver, Karl
  last_name: Annusver
- first_name: Maria
  full_name: Kasper, Maria
  last_name: Kasper
- first_name: Orsolya
  full_name: Symmons, Orsolya
  last_name: Symmons
- first_name: Leslie
  full_name: Pan, Leslie
  last_name: Pan
- first_name: Francois
  full_name: Spitz, Francois
  last_name: Spitz
- first_name: Jozef
  full_name: Kaiser, Jozef
  last_name: Kaiser
- first_name: Maria
  full_name: Hovorakova, Maria
  last_name: Hovorakova
- first_name: Tomas
  full_name: Zikmund, Tomas
  last_name: Zikmund
- first_name: Kazunori
  full_name: Sunadome, Kazunori
  last_name: Sunadome
- first_name: Michael P
  full_name: Matise, Michael P
  last_name: Matise
- first_name: Hui
  full_name: Wang, Hui
  last_name: Wang
- first_name: Ulrika
  full_name: Marklund, Ulrika
  last_name: Marklund
- first_name: Hind
  full_name: Abdo, Hind
  last_name: Abdo
- first_name: Patrik
  full_name: Ernfors, Patrik
  last_name: Ernfors
- first_name: Pascal
  full_name: Maire, Pascal
  last_name: Maire
- first_name: Maud
  full_name: Wurmser, Maud
  last_name: Wurmser
- first_name: Andrei S
  full_name: Chagin, Andrei S
  last_name: Chagin
- first_name: Kaj
  full_name: Fried, Kaj
  last_name: Fried
- first_name: Igor
  full_name: Adameyko, Igor
  last_name: Adameyko
citation:
  ama: 'Kaucka M, Petersen J, Tesarova M, et al. Data from: Signals from the brain
    and olfactory epithelium control shaping of the mammalian nasal capsule cartilage.
    2018. doi:<a href="https://doi.org/10.5061/dryad.f1s76f2">10.5061/dryad.f1s76f2</a>'
  apa: 'Kaucka, M., Petersen, J., Tesarova, M., Szarowska, B., Kastriti, M. E., Xie,
    M., … Adameyko, I. (2018). Data from: Signals from the brain and olfactory epithelium
    control shaping of the mammalian nasal capsule cartilage. Dryad. <a href="https://doi.org/10.5061/dryad.f1s76f2">https://doi.org/10.5061/dryad.f1s76f2</a>'
  chicago: 'Kaucka, Marketa, Julian Petersen, Marketa Tesarova, Bara Szarowska, Maria
    Eleni Kastriti, Meng Xie, Anna Kicheva, et al. “Data from: Signals from the Brain
    and Olfactory Epithelium Control Shaping of the Mammalian Nasal Capsule Cartilage.”
    Dryad, 2018. <a href="https://doi.org/10.5061/dryad.f1s76f2">https://doi.org/10.5061/dryad.f1s76f2</a>.'
  ieee: 'M. Kaucka <i>et al.</i>, “Data from: Signals from the brain and olfactory
    epithelium control shaping of the mammalian nasal capsule cartilage.” Dryad, 2018.'
  ista: 'Kaucka M, Petersen J, Tesarova M, Szarowska B, Kastriti ME, Xie M, Kicheva
    A, Annusver K, Kasper M, Symmons O, Pan L, Spitz F, Kaiser J, Hovorakova M, Zikmund
    T, Sunadome K, Matise MP, Wang H, Marklund U, Abdo H, Ernfors P, Maire P, Wurmser
    M, Chagin AS, Fried K, Adameyko I. 2018. Data from: Signals from the brain and
    olfactory epithelium control shaping of the mammalian nasal capsule cartilage,
    Dryad, <a href="https://doi.org/10.5061/dryad.f1s76f2">10.5061/dryad.f1s76f2</a>.'
  mla: 'Kaucka, Marketa, et al. <i>Data from: Signals from the Brain and Olfactory
    Epithelium Control Shaping of the Mammalian Nasal Capsule Cartilage</i>. Dryad,
    2018, doi:<a href="https://doi.org/10.5061/dryad.f1s76f2">10.5061/dryad.f1s76f2</a>.'
  short: M. Kaucka, J. Petersen, M. Tesarova, B. Szarowska, M.E. Kastriti, M. Xie,
    A. Kicheva, K. Annusver, M. Kasper, O. Symmons, L. Pan, F. Spitz, J. Kaiser, M.
    Hovorakova, T. Zikmund, K. Sunadome, M.P. Matise, H. Wang, U. Marklund, H. Abdo,
    P. Ernfors, P. Maire, M. Wurmser, A.S. Chagin, K. Fried, I. Adameyko, (2018).
date_created: 2021-08-09T12:54:35Z
date_published: 2018-06-14T00:00:00Z
date_updated: 2025-04-14T13:02:22Z
day: '14'
department:
- _id: AnKi
doi: 10.5061/dryad.f1s76f2
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5061/dryad.f1s76f2
month: '06'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
  record:
  - id: '162'
    relation: used_in_publication
    status: public
status: public
title: 'Data from: Signals from the brain and olfactory epithelium control shaping
  of the mammalian nasal capsule cartilage'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2018'
...