---
res:
  bibo_abstract:
  - Adult height inspired the first biometrical and quantitative genetic studies and
    is a test-case trait for understanding heritability. The studies of height led
    to formulation of the classical polygenic model, that has a profound influence
    on the way we view and analyse complex traits. An essential part of the classical
    model is an assumption of additivity of effects and normality of the distribution
    of the residuals. However, it may be expected that the normal approximation will
    become insufficient in bigger studies. Here, we demonstrate that when the height
    of hundreds of thousands of individuals is analysed, the model complexity needs
    to be increased to include non-additive interactions between sex, environment
    and genes. Alternatively, the use of log-normal approximation allowed us to still
    use the additive effects model. These findings are important for future genetic
    and methodologic studies that make use of adult height as an exemplar trait.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Sergei A.
      foaf_name: Slavskii, Sergei A.
      foaf_surname: Slavskii
  - foaf_Person:
      foaf_givenName: Ivan A.
      foaf_name: Kuznetsov, Ivan A.
      foaf_surname: Kuznetsov
  - foaf_Person:
      foaf_givenName: Tatiana I.
      foaf_name: Shashkova, Tatiana I.
      foaf_surname: Shashkova
  - foaf_Person:
      foaf_givenName: Georgii A.
      foaf_name: Bazykin, Georgii A.
      foaf_surname: Bazykin
  - foaf_Person:
      foaf_givenName: Tatiana I.
      foaf_name: Axenovich, Tatiana I.
      foaf_surname: Axenovich
  - foaf_Person:
      foaf_givenName: Fyodor
      foaf_name: Kondrashov, Fyodor
      foaf_surname: Kondrashov
      foaf_workInfoHomepage: http://www.librecat.org/personId=44FDEF62-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8243-4694
  - foaf_Person:
      foaf_givenName: Yurii S.
      foaf_name: Aulchenko, Yurii S.
      foaf_surname: Aulchenko
  bibo_doi: 10.1038/s41431-021-00836-7
  bibo_issue: '7'
  bibo_volume: 29
  dct_date: 2021^xs_gYear
  dct_identifier:
  - UT:000625853200001
  dct_isPartOf:
  - http://id.crossref.org/issn/1018-4813
  - http://id.crossref.org/issn/1476-5438
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: The limits of normal approximation for adult height@
  fabio_hasPubmedId: '33664501'
...