---
_id: '9930'
abstract:
- lang: eng
  text: Adaptive divergence and speciation may happen despite opposition by gene flow.
    Identifying the genomic basis underlying divergence with gene flow is a major
    task in evolutionary genomics. Most approaches (e.g. outlier scans) focus on genomic
    regions of high differentiation. However, not all genomic architectures potentially
    underlying divergence are expected to show extreme differentiation. Here, we develop
    an approach that combines hybrid zone analysis (i.e. focuses on spatial patterns
    of allele frequency change) with system-specific simulations to identify loci
    inconsistent with neutral evolution. We apply this to a genome-wide SNP set from
    an ideally-suited study organism, the intertidal snail Littorina saxatilis, which
    shows primary divergence between ecotypes associated with different shore habitats.
    We detect many SNPs with clinal patterns, most of which are consistent with neutrality.
    Among non-neutral SNPs, most are located within three large putative inversions
    differentiating ecotypes. Many non-neutral SNPs show relatively low levels of
    differentiation. We discuss potential reasons for this pattern, including loose
    linkage to selected variants, polygenic adaptation and a component of balancing
    selection within populations (which may be expected for inversions). Our work
    is in line with theory predicting a role for inversions in divergence, and emphasises
    that genomic regions contributing to divergence may not always be accessible with
    methods purely based on allele frequency differences. These conclusions call for
    approaches that take spatial patterns of allele frequency change into account
    in other systems.
article_processing_charge: No
author:
- first_name: Anja M
  full_name: Westram, Anja M
  id: 3C147470-F248-11E8-B48F-1D18A9856A87
  last_name: Westram
  orcid: 0000-0003-1050-4969
- first_name: Marina
  full_name: Rafajlović, Marina
  last_name: Rafajlović
- first_name: Pragya
  full_name: Chaube, Pragya
  last_name: Chaube
- first_name: Rui
  full_name: Faria, Rui
  last_name: Faria
- first_name: Tomas
  full_name: Larsson, Tomas
  last_name: Larsson
- first_name: Marina
  full_name: Panova, Marina
  last_name: Panova
- first_name: Mark
  full_name: Ravinet, Mark
  last_name: Ravinet
- first_name: Anders
  full_name: Blomberg, Anders
  last_name: Blomberg
- first_name: Bernhard
  full_name: Mehlig, Bernhard
  last_name: Mehlig
- first_name: Kerstin
  full_name: Johannesson, Kerstin
  last_name: Johannesson
- first_name: Roger
  full_name: Butlin, Roger
  last_name: Butlin
citation:
  ama: 'Westram AM, Rafajlović M, Chaube P, et al. Data from: Clines on the seashore:
    the genomic architecture underlying rapid divergence in the face of gene flow.
    2018. doi:<a href="https://doi.org/10.5061/dryad.bp25b65">10.5061/dryad.bp25b65</a>'
  apa: 'Westram, A. M., Rafajlović, M., Chaube, P., Faria, R., Larsson, T., Panova,
    M., … Butlin, R. (2018). Data from: Clines on the seashore: the genomic architecture
    underlying rapid divergence in the face of gene flow. Dryad. <a href="https://doi.org/10.5061/dryad.bp25b65">https://doi.org/10.5061/dryad.bp25b65</a>'
  chicago: 'Westram, Anja M, Marina Rafajlović, Pragya Chaube, Rui Faria, Tomas Larsson,
    Marina Panova, Mark Ravinet, et al. “Data from: Clines on the Seashore: The Genomic
    Architecture Underlying Rapid Divergence in the Face of Gene Flow.” Dryad, 2018.
    <a href="https://doi.org/10.5061/dryad.bp25b65">https://doi.org/10.5061/dryad.bp25b65</a>.'
  ieee: 'A. M. Westram <i>et al.</i>, “Data from: Clines on the seashore: the genomic
    architecture underlying rapid divergence in the face of gene flow.” Dryad, 2018.'
  ista: 'Westram AM, Rafajlović M, Chaube P, Faria R, Larsson T, Panova M, Ravinet
    M, Blomberg A, Mehlig B, Johannesson K, Butlin R. 2018. Data from: Clines on the
    seashore: the genomic architecture underlying rapid divergence in the face of
    gene flow, Dryad, <a href="https://doi.org/10.5061/dryad.bp25b65">10.5061/dryad.bp25b65</a>.'
  mla: 'Westram, Anja M., et al. <i>Data from: Clines on the Seashore: The Genomic
    Architecture Underlying Rapid Divergence in the Face of Gene Flow</i>. Dryad,
    2018, doi:<a href="https://doi.org/10.5061/dryad.bp25b65">10.5061/dryad.bp25b65</a>.'
  short: A.M. Westram, M. Rafajlović, P. Chaube, R. Faria, T. Larsson, M. Panova,
    M. Ravinet, A. Blomberg, B. Mehlig, K. Johannesson, R. Butlin, (2018).
date_created: 2021-08-17T08:58:47Z
date_published: 2018-07-23T00:00:00Z
date_updated: 2024-10-21T06:02:42Z
day: '23'
department:
- _id: BeVi
doi: 10.5061/dryad.bp25b65
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5061/dryad.bp25b65
month: '07'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
  record:
  - id: '9917'
    relation: used_in_publication
    status: public
status: public
title: 'Data from: Clines on the seashore: the genomic architecture underlying rapid
  divergence in the face of gene flow'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2018'
...