---
res:
  bibo_abstract:
  - The brain is one of the largest and most complex organs and it is composed of
    billions of neurons that communicate together enabling e.g. consciousness. The
    cerebral cortex is the largest site of neural integration in the central nervous
    system. Concerted radial migration of newly born cortical projection neurons,
    from their birthplace to their final position, is a key step in the assembly of
    the cerebral cortex. The cellular and molecular mechanisms regulating radial neuronal
    migration in vivo are however still unclear. Recent evidence suggests that distinct
    signaling cues act cell-autonomously but differentially at certain steps during
    the overall migration process. Moreover, functional analysis of genetic mosaics
    (mutant neurons present in wild-type/heterozygote environment) using the MADM
    (Mosaic Analysis with Double Markers) analyses in comparison to global knockout
    also indicate a significant degree of non-cell-autonomous and/or community effects
    in the control of cortical neuron migration. The interactions of cell-intrinsic
    (cell-autonomous) and cell-extrinsic (non-cell-autonomous) components are largely
    unknown. In part of this thesis work we established a MADM-based experimental
    strategy for the quantitative analysis of cell-autonomous gene function versus
    non-cell-autonomous and/or community effects. The direct comparison of mutant
    neurons from the genetic mosaic (cell-autonomous) to mutant neurons in the conditional
    and/or global knockout (cell-autonomous + non-cell-autonomous) allows to quantitatively
    analyze non-cell-autonomous effects. Such analysis enable the high-resolution
    analysis of projection neuron migration dynamics in distinct environments with
    concomitant isolation of genomic and proteomic profiles. Using these experimental
    paradigms and in combination with computational modeling we show and characterize
    the nature of non-cell-autonomous effects to coordinate radial neuron migration.
    Furthermore, this thesis discusses recent developments in neurodevelopment with
    focus on neuronal polarization and non-cell-autonomous mechanisms in neuronal
    migration.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Andi H
      foaf_name: Hansen, Andi H
      foaf_surname: Hansen
      foaf_workInfoHomepage: http://www.librecat.org/personId=38853E16-F248-11E8-B48F-1D18A9856A87
  bibo_doi: 10.15479/at:ista:9962
  dct_date: 2021^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2663-337X
  dct_language: eng
  dct_publisher: Institute of Science and Technology Austria@
  dct_subject:
  - Neuronal migration
  - Non-cell-autonomous
  - Cell-autonomous
  - Neurodevelopmental disease
  dct_title: Cell-autonomous gene function and non-cell-autonomous effects in radial
    projection neuron migration@
...