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126 Publications


2020 | Journal Article | IST-REx-ID: 7623 | OA
Modeling adhesion-independent cell migration
G. Jankowiak, D. Peurichard, A. Reversat, C. Schmeiser, M.K. Sixt, Mathematical Models and Methods in Applied Sciences 30 (2020) 513–537.
[Preprint] View | DOI | Download Preprint (ext.) | WoS | arXiv
 

2020 | Journal Article | IST-REx-ID: 7875 | OA
Microtubules control cellular shape and coherence in amoeboid migrating cells
A. Kopf, J. Renkawitz, R. Hauschild, I. Girkontaite, K. Tedford, J. Merrin, O. Thorn-Seshold, D. Trauner, H. Häcker, K.D. Fischer, E. Kiermaier, M.K. Sixt, The Journal of Cell Biology 219 (2020).
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2020 | Journal Article | IST-REx-ID: 7876 | OA
T cells: Bridge-and-channel commute to the white pulp
M.K. Sixt, T. Lämmermann, Immunity 52 (2020) 721–723.
[Published Version] View | DOI | Download Published Version (ext.) | WoS
 

2020 | Journal Article | IST-REx-ID: 7909 | OA
Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion
J. Damiano-Guercio, L. Kurzawa, J. Müller, G.A. Dimchev, M. Schaks, M. Nemethova, T. Pokrant, S. Brühmann, J. Linkner, L. Blanchoin, M.K. Sixt, K. Rottner, J. Faix, ELife 9 (2020).
[Published Version] View | Files available | DOI | WoS
 

2020 | Journal Article | IST-REx-ID: 8132
The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity
Salzer E, Zoghi S, Kiss MG, Kage F, Rashkova C, Stahnke S, Haimel M, Platzer R, Caldera M, Ardy RC, Hoeger B, Block J, Medgyesi D, Sin C, Shahkarami S, Kain R, Ziaee V, Hammerl P, Bock C, Menche J, Dupré L, Huppa JB, Sixt MK, Lomakin A, Rottner K, Binder CJ, Stradal TEB, Rezaei N, Boztug K. 2020. The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity. Science Immunology. 5(49), eabc3979.
View | DOI | WoS | PubMed | Europe PMC
 

2020 | Journal Article | IST-REx-ID: 8787 | OA
Vascular surveillance by haptotactic blood platelets in inflammation and infection
Nicolai L, Schiefelbein K, Lipsky S, Leunig A, Hoffknecht M, Pekayvaz K, Raude B, Marx C, Ehrlich A, Pircher J, Zhang Z, Saleh I, Marel A-K, Löf A, Petzold T, Lorenz M, Stark K, Pick R, Rosenberger G, Weckbach L, Uhl B, Xia S, Reichel CA, Walzog B, Schulz C, Zheden V, Bender M, Li R, Massberg S, Gärtner FR. 2020. Vascular surveillance by haptotactic blood platelets in inflammation and infection. Nature Communications. 11, 5778.
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2020 | Journal Article | IST-REx-ID: 8142 | OA
Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage
J.C. Montesinos López, A. Abuzeineh, A. Kopf, A. Juanes Garcia, K. Ötvös, J. Petrášek, M.K. Sixt, E. Benková, The Embo Journal 39 (2020).
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2020 | Journal Article | IST-REx-ID: 7885
Cellular locomotion using environmental topography
A. Reversat, F.R. Gärtner, J. Merrin, J.A. Stopp, S. Tasciyan, J.L. Aguilera Servin, I. de Vries, R. Hauschild, M. Hons, M. Piel, A. Callan-Jones, R. Voituriez, M.K. Sixt, Nature 582 (2020) 582–585.
View | Files available | DOI | WoS
 

2020 | Journal Article | IST-REx-ID: 8190 | OA
Zena Werb (1945-2020): Cell biology in context
M.K. Sixt, A. Huttenlocher, The Journal of Cell Biology 219 (2020).
[Published Version] View | Files available | DOI | WoS
 

2019 | Journal Article | IST-REx-ID: 6824
Patrolling the vascular borders: Platelets in immunity to infection and cancer
F.R. Gärtner, S. Massberg, Nature Reviews Immunology 19 (2019) 747–760.
View | DOI | WoS | PubMed | Europe PMC
 

2019 | Journal Article | IST-REx-ID: 7009
Mechanisms of 3D cell migration
K. Yamada, M.K. Sixt, Nature Reviews Molecular Cell Biology 20 (2019) 738–752.
View | DOI | WoS | PubMed | Europe PMC
 

2019 | Journal Article | IST-REx-ID: 6988
Platelets in host defense: Experimental and clinical insights
L. Nicolai, F.R. Gärtner, S. Massberg, Trends in Immunology 40 (2019) 922–938.
View | DOI | WoS | PubMed | Europe PMC
 

2019 | Journal Article | IST-REx-ID: 6979
Gut homeostasis: Active migration of intestinal epithelial cells in tissue renewal
A. Kopf, M.K. Sixt, Current Biology 29 (2019) R1091–R1093.
View | DOI | WoS | PubMed | Europe PMC
 

2019 | Journal Article | IST-REx-ID: 7105 | OA
Persistent and polarized global actin flow is essential for directionality during cell migration
L. Yolland, M. Burki, S. Marcotti, A. Luchici, F.N. Kenny, J.R. Davis, E. Serna-Morales, J. Müller, M.K. Sixt, A. Davidson, W. Wood, L.J. Schumacher, R.G. Endres, M. Miodownik, B.M. Stramer, Nature Cell Biology 21 (2019) 1370–1381.
[Submitted Version] View | DOI | Download Submitted Version (ext.) | WoS | PubMed | Europe PMC
 

2019 | Journal Article | IST-REx-ID: 7420 | OA
GGA2 and RAB13 promote activity-dependent β1-integrin recycling
P. Sahgal, J.H. Alanko, J. Icha, I. Paatero, H. Hamidi, A. Arjonen, M. Pietilä, A. Rokka, J. Ivaska, Journal of Cell Science 132 (2019).
[Published Version] View | DOI | Download Published Version (ext.) | WoS | PubMed | Europe PMC
 

2019 | Journal Article | IST-REx-ID: 7404 | OA
Transient localization of the Arp2/3 complex initiates neuronal dendrite branching in vivo
T. Stürner, A. Tatarnikova, J. Müller, B. Schaffran, H. Cuntz, Y. Zhang, M. Nemethova, S. Bogdan, V. Small, G. Tavosanis, Development 146 (2019).
[Published Version] View | DOI | Download Published Version (ext.) | WoS | PubMed | Europe PMC
 

2019 | Thesis | IST-REx-ID: 6947 | OA
Lymph node mechanics: Deciphering the interplay between stroma contractility, morphology and lymphocyte trafficking
F.P. Assen, Lymph Node Mechanics: Deciphering the Interplay between Stroma Contractility, Morphology and Lymphocyte Trafficking, Institute of Science and Technology Austria, 2019.
[Published Version] View | Files available | DOI
 

2019 | Thesis | IST-REx-ID: 6891 | OA
The implication of cytoskeletal dynamics on leukocyte migration
A. Kopf, The Implication of Cytoskeletal Dynamics on Leukocyte Migration, Institute of Science and Technology Austria, 2019.
[Published Version] View | Files available | DOI
 

2019 | Journal Article | IST-REx-ID: 6328 | OA
Nuclear positioning facilitates amoeboid migration along the path of least resistance
J. Renkawitz, A. Kopf, J.A. Stopp, I. de Vries, M.K. Driscoll, J. Merrin, R. Hauschild, E.S. Welf, G. Danuser, R. Fiolka, M.K. Sixt, Nature 568 (2019) 546–550.
[Submitted Version] View | Files available | DOI | Download Submitted Version (ext.) | WoS | PubMed | Europe PMC
 

2019 | Journal Article | IST-REx-ID: 6877
The neural crest pitches in to remove apoptotic debris
A. Kopf, M.K. Sixt, Cell 179 (2019) 51–53.
View | Files available | DOI | WoS | PubMed | Europe PMC
 

2018 | Journal Article | IST-REx-ID: 6354 | OA
Platelet migration and bacterial trapping assay under flow
S. Fan, M. Lorenz, S. Massberg, F.R. Gärtner, Bio-Protocol 8 (2018).
[Published Version] View | Files available | DOI
 

2018 | Journal Article | IST-REx-ID: 318 | OA
A fat lot of good for wound healing
A.M. Casano, M.K. Sixt, Developmental Cell 44 (2018) 405–406.
[Published Version] View | DOI | Download Published Version (ext.) | WoS | PubMed | Europe PMC
 

2018 | Journal Article | IST-REx-ID: 308 | OA
Drosophila TNF modulates tissue tension in the embryo to facilitate macrophage invasive migration
A. Ratheesh, J. Bicher, M. Smutny, J. Veselá, E. Papusheva, G. Krens, W. Kaufmann, A. György, A.M. Casano, D.E. Siekhaus, Developmental Cell 45 (2018) 331–346.
[Published Version] View | Files available | DOI | Download Published Version (ext.) | WoS | PubMed | Europe PMC
 

2018 | Journal Article | IST-REx-ID: 437 | OA
Fast and efficient genetic engineering of hematopoietic precursor cells for the study of dendritic cell migration
A.F. Leithner, J. Renkawitz, I. de Vries, R. Hauschild, H. Haecker, M.K. Sixt, European Journal of Immunology 48 (2018) 1074–1077.
[Published Version] View | Files available | DOI | WoS
 

2018 | Journal Article | IST-REx-ID: 5672 | OA
IgM's exit route
A. Reversat, M.K. Sixt, Journal of Experimental Medicine 215 (2018) 2959–2961.
[Published Version] View | Files available | DOI | WoS
 

2018 | Journal Article | IST-REx-ID: 275 | OA
Lymphatic exosomes promote dendritic cell migration along guidance cues
M. Brown, L. Johnson, D. Leone, P. Májek, K. Vaahtomeri, D. Senfter, N. Bukosza, H. Schachner, G. Asfour, B. Langer, R. Hauschild, K. Parapatics, Y. Hong, K. Bennett, R. Kain, M. Detmar, M.K. Sixt, D. Jackson, D. Kerjaschki, Journal of Cell Biology 217 (2018) 2205–2221.
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2018 | Journal Article | IST-REx-ID: 5858 | OA
Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data
S. Hross, F.J. Theis, M.K. Sixt, J. Hasenauer, Journal of the Royal Society Interface 15 (2018).
[Published Version] View | Files available | DOI | WoS
 

2018 | Book Chapter | IST-REx-ID: 153
Micro-engineered “pillar forests” to study cell migration in complex but controlled 3D environments
J. Renkawitz, A. Reversat, A.F. Leithner, J. Merrin, M.K. Sixt, in:, Methods in Cell Biology, Academic Press, 2018, pp. 79–91.
View | DOI | WoS | PubMed | Europe PMC
 

2018 | Journal Article | IST-REx-ID: 276 | OA
Nano-scale microfluidics to study 3D chemotaxis at the single cell level
C. Frick, P. Dettinger, J. Renkawitz, A. Jauch, C. Berger, M. Recher, T. Schroeder, M. Mehling, PLoS One 13 (2018).
[Published Version] View | Files available | DOI | WoS
 

2018 | Journal Article | IST-REx-ID: 5861 | OA
The cell sets the tone
J.H. Alanko, M.K. Sixt, ELife 7 (2018).
[Published Version] View | Files available | DOI | WoS
 

2018 | Journal Article | IST-REx-ID: 5984 | OA
Optical functionalization of human class A orphan G-protein-coupled receptors
M. Morri, I. Sanchez-Romero, A.-M. Tichy, S. Kainrath, E.J. Gerrard, P. Hirschfeld, J. Schwarz, H.L. Janovjak, Nature Communications 9 (2018).
[Published Version] View | Files available | DOI | WoS
 

2018 | Journal Article | IST-REx-ID: 5992 | OA
On the relation between filament density, force generation, and protrusion rate in mesenchymal cell motility
S. Dolati, F. Kage, J. Mueller, M. Müsken, M. Kirchner, G. Dittmar, M.K. Sixt, K. Rottner, M. Falcke, Molecular Biology of the Cell 29 (2018) 2674–2686.
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

2018 | Journal Article | IST-REx-ID: 6497 | OA
The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+T cells
F. Moalli, X. Ficht, P. Germann, M. Vladymyrov, B. Stolp, I. de Vries, R. Lyck, J. Balmer, A. Fiocchi, M. Kreutzfeldt, D. Merkler, M. Iannacone, A. Ariga, M.H. Stoffel, J. Sharpe, M. Bähler, M.K. Sixt, A. Diz-Muñoz, J.V. Stein, The Journal of Experimental Medicine 2015 (2018) 1869–1890.
[Published Version] View | Files available | DOI | WoS
 

2018 | Journal Article | IST-REx-ID: 402 | OA
Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice
M. Brown, F.P. Assen, A.F. Leithner, J. Abe, H. Schachner, G. Asfour, Z. Bagó Horváth, J. Stein, P. Uhrin, M.K. Sixt, D. Kerjaschki, Science 359 (2018) 1408–1411.
[Published Version] View | Files available | DOI | Download Published Version (ext.) | WoS | PubMed | Europe PMC
 

2018 | Thesis | IST-REx-ID: 323 | OA
Branched actin networks in dendritic cell biology
A.F. Leithner, Branched Actin Networks in Dendritic Cell Biology, Institute of Science and Technology Austria, 2018.
[Published Version] View | Files available | DOI
 

2018 | Journal Article | IST-REx-ID: 15 | OA
Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells
M. Hons, A. Kopf, R. Hauschild, A.F. Leithner, F.R. Gärtner, J. Abe, J. Renkawitz, J. Stein, M.K. Sixt, Nature Immunology 19 (2018) 606–616.
[Published Version] View | Files available | DOI | Download Published Version (ext.) | WoS | PubMed | Europe PMC
 

2017 | Journal Article | IST-REx-ID: 569 | OA
Cytokinesis in vertebrate cells initiates by contraction of an equatorial actomyosin network composed of randomly oriented filaments
F. Spira, S. Cuylen Haering, S. Mehta, M. Samwer, A. Reversat, A. Verma, R. Oldenbourg, M.K. Sixt, D. Gerlich, ELife 6 (2017).
[Published Version] View | Files available | DOI
 

2017 | Journal Article | IST-REx-ID: 571
Migrating platelets are mechano scavengers that collect and bundle bacteria
Gärtner FR, Ahmad Z, Rosenberger G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Ishikawa Ankerhold H, Hennel R, Benechet A, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Böttcher R, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos Y Schnitzler M, Pincus Z, Iannacone M, Haas R, Wanner G, Lauber K, Sixt MK, Massberg S. 2017. Migrating platelets are mechano scavengers that collect and bundle bacteria. Cell Press. 171(6), 1368–1382.
View | DOI
 

2017 | Journal Article | IST-REx-ID: 659 | OA
FMNL formins boost lamellipodial force generation
F. Kage, M. Winterhoff, V. Dimchev, J. Müller, T. Thalheim, A. Freise, S. Brühmann, J. Kollasser, J. Block, G.A. Dimchev, M. Geyer, H. Schnittler, C. Brakebusch, T. Stradal, M. Carlier, M.K. Sixt, J. Käs, J. Faix, K. Rottner, Nature Communications 8 (2017).
[Published Version] View | Files available | DOI
 

2017 | Journal Article | IST-REx-ID: 668 | OA
Multiple roles of filopodial dynamics in particle capture and phagocytosis and phenotypes of Cdc42 and Myo10 deletion
M. Horsthemke, A. Bachg, K. Groll, S. Moyzio, B. Müther, S. Hemkemeyer, R. Wedlich Söldner, M.K. Sixt, S. Tacke, M. Bähler, P. Hanley, Journal of Biological Chemistry 292 (2017) 7258–7273.
[Published Version] View | Files available | DOI
 

2017 | Journal Article | IST-REx-ID: 672 | OA
Locally triggered release of the chemokine CCL21 promotes dendritic cell transmigration across lymphatic endothelia
K. Vaahtomeri, M. Brown, R. Hauschild, I. de Vries, A.F. Leithner, M. Mehling, W. Kaufmann, M.K. Sixt, Cell Reports 19 (2017) 902–909.
[Published Version] View | Files available | DOI
 

2017 | Journal Article | IST-REx-ID: 674
Dendritic cells interpret haptotactic chemokine gradients in a manner governed by signal to noise ratio and dependent on GRK6
J. Schwarz, V. Bierbaum, K. Vaahtomeri, R. Hauschild, M. Brown, I. de Vries, A.F. Leithner, A. Reversat, J. Merrin, T. Tarrant, M.T. Bollenbach, M.K. Sixt, Current Biology 27 (2017) 1314–1325.
View | DOI
 

2017 | Journal Article | IST-REx-ID: 677 | OA
The INO80 complex removes H2A.Z to promote presynaptic filament formation during homologous recombination
C. Lademann, J. Renkawitz, B. Pfander, S. Jentsch, Cell Reports 19 (2017) 1294–1303.
[Published Version] View | Files available | DOI
 

2017 | Journal Article | IST-REx-ID: 694 | OA
A dual phenotype of MDA MB 468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity
A. Veß, U. Blache, L. Leitner, A. Kurz, A. Ehrenpfordt, M.K. Sixt, G. Posern, Journal of Cell Science 130 (2017) 2172–2184.
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 

2017 | Journal Article | IST-REx-ID: 1161
Cell migration: Making the waves
J. Müller, M.K. Sixt, Current Biology 27 (2017) R24–R25.
View | DOI | WoS
 

2017 | Journal Article | IST-REx-ID: 727
Load adaptation of lamellipodial actin networks
J. Mueller, G. Szep, M. Nemethova, I. de Vries, A. Lieber, C. Winkler, K. Kruse, J. Small, C. Schmeiser, K. Keren, R. Hauschild, M.K. Sixt, Cell 171 (2017) 188–200.
View | DOI | WoS
 

2017 | Research Data | IST-REx-ID: 5567 | OA
Immunological synapse DC-Tcells
A.F. Leithner, (2017).
[Published Version] View | Files available | DOI
 

2017 | Journal Article | IST-REx-ID: 664
The dynamic cytokine niche
F.P. Assen, M.K. Sixt, Immunity 46 (2017) 519–520.
View | Files available | DOI
 

2017 | Journal Article | IST-REx-ID: 679 | OA
The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection
F. Ebner, V. Sedlyarov, S. Tasciyan, M. Ivin, F. Kratochvill, N. Gratz, L. Kenner, A. Villunger, M.K. Sixt, P. Kovarik, The Journal of Clinical Investigation 127 (2017) 2051–2065.
[Submitted Version] View | Files available | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 

2016 | Journal Article | IST-REx-ID: 1137 | OA
RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics
Salzer E, Çaǧdaş D, Hons M, Mace E, Garncarz W, Petronczki O, Platzer R, Pfajfer L, Bilic I, Ban S, Willmann K, Mukherjee M, Supper V, Hsu H, Banerjee P, Sinha P, Mcclanahan F, Zlabinger G, Pickl W, Gribben J, Stockinger H, Bennett K, Huppa J, Dupré L, Sanal Ö, Jäger U, Sixt MK, Tezcan I, Orange J, Boztug K. 2016. RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics. Nature Immunology. 17(12), 1352–1360.
[Submitted Version] View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 

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