Margaret E Maes
Siegert Group
12 Publications
2025 | Published | Journal Article | IST-REx-ID: 19566 |

Optic nerve crush does not induce retinal ganglion cell loss in the contralateral eye
Schoot Uiterkamp, Florianne E, Optic nerve crush does not induce retinal ganglion cell loss in the contralateral eye. Investigative Ophthalmology & Visual Science 66 (3). 2025
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Schoot Uiterkamp, Florianne E, Optic nerve crush does not induce retinal ganglion cell loss in the contralateral eye. Investigative Ophthalmology & Visual Science 66 (3). 2025
2023 | Published | Journal Article | IST-REx-ID: 14363 |

Mitochondrial network adaptations of microglia reveal sex-specific stress response after injury and UCP2 knockout
M.E. Maes, G. Colombo, F.E. Schoot Uiterkamp, F. Sternberg, A. Venturino, E.E. Pohl, S. Siegert, IScience 26 (2023).
[Published Version]
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M.E. Maes, G. Colombo, F.E. Schoot Uiterkamp, F. Sternberg, A. Venturino, E.E. Pohl, S. Siegert, IScience 26 (2023).
2023 | Published | Journal Article | IST-REx-ID: 14401 |

BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps
M.E. Maes, R.J. Donahue, C.L. Schlamp, O.J. Marola, R.T. Libby, R.W. Nickells, Molecular Neurodegeneration 18 (2023).
[Published Version]
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| DOI
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| PubMed | Europe PMC
M.E. Maes, R.J. Donahue, C.L. Schlamp, O.J. Marola, R.T. Libby, R.W. Nickells, Molecular Neurodegeneration 18 (2023).
2021 | Published | Journal Article | IST-REx-ID: 10000 |

Increased susceptibility and intrinsic apoptotic signaling in neurons by induced HDAC3 expression
H.M. Schmitt, R.L. Fehrman, M.E. Maes, H. Yang, L.W. Guo, C.L. Schlamp, H.R. Pelzel, R.W. Nickells, Investigative Ophthalmology and Visual Science 62 (2021).
[Published Version]
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| Files available
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| PubMed | Europe PMC
H.M. Schmitt, R.L. Fehrman, M.E. Maes, H. Yang, L.W. Guo, C.L. Schlamp, H.R. Pelzel, R.W. Nickells, Investigative Ophthalmology and Visual Science 62 (2021).
2021 | Published | Journal Article | IST-REx-ID: 9761 |

The influence of mitochondrial dynamics and function on retinal ganglion cell susceptibility in optic nerve disease
N.A. Muench, S. Patel, M.E. Maes, R.J. Donahue, A. Ikeda, R.W. Nickells, Cells 10 (2021).
[Published Version]
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| Files available
| DOI
| WoS
| PubMed | Europe PMC
N.A. Muench, S. Patel, M.E. Maes, R.J. Donahue, A. Ikeda, R.W. Nickells, Cells 10 (2021).
2021 | Published | Journal Article | IST-REx-ID: 9009 |

Characteristics of intracellular propagation of mitochondrial BAX recruitment during apoptosis
J.A. Grosser, M.E. Maes, R.W. Nickells, Apoptosis 26 (2021) 132–145.
[Submitted Version]
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| DOI
| Download Submitted Version (ext.)
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| PubMed | Europe PMC
J.A. Grosser, M.E. Maes, R.W. Nickells, Apoptosis 26 (2021) 132–145.
2021 | Published | Journal Article | IST-REx-ID: 9642 |

Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain
A. Venturino, R. Schulz, H. De Jesús-Cortés, M.E. Maes, B. Nagy, F. Reilly-Andújar, G. Colombo, R.J. Cubero, F.E. Schoot Uiterkamp, M.F. Bear, S. Siegert, Cell Reports 36 (2021).
[Published Version]
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| Files available
| DOI
| WoS
| PubMed | Europe PMC
A. Venturino, R. Schulz, H. De Jesús-Cortés, M.E. Maes, B. Nagy, F. Reilly-Andújar, G. Colombo, R.J. Cubero, F.E. Schoot Uiterkamp, M.F. Bear, S. Siegert, Cell Reports 36 (2021).
2021 | Published | Journal Article | IST-REx-ID: 10655 |

Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment
M.E. Maes, G.M. Wögenstein, G. Colombo, R. Casado Polanco, S. Siegert, Molecular Therapy - Methods and Clinical Development 23 (2021) 210–224.
[Published Version]
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| Files available
| DOI
| WoS
M.E. Maes, G.M. Wögenstein, G. Colombo, R. Casado Polanco, S. Siegert, Molecular Therapy - Methods and Clinical Development 23 (2021) 210–224.
2020 | Published | Journal Article | IST-REx-ID: 7033 |

BAX-depleted retinal ganglion cells survive and become quiescent following optic nerve damage
R. Donahue, M.E. Maes, J. Grosser, R. Nickells, Molecular Neurobiology 57 (2020) 1070–1084.
[Submitted Version]
View
| DOI
| Download Submitted Version (ext.)
| WoS
| PubMed | Europe PMC
R. Donahue, M.E. Maes, J. Grosser, R. Nickells, Molecular Neurobiology 57 (2020) 1070–1084.
2019 | Published | Journal Article | IST-REx-ID: 7095 |

Completion of BAX recruitment correlates with mitochondrial fission during apoptosis
M.E. Maes, J.A. Grosser, R.L. Fehrman, C.L. Schlamp, R.W. Nickells, Scientific Reports 9 (2019).
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
M.E. Maes, J.A. Grosser, R.L. Fehrman, C.L. Schlamp, R.W. Nickells, Scientific Reports 9 (2019).
2019 | Published | Journal Article | IST-REx-ID: 6521 |

Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges
M.E. Maes, G. Colombo, R. Schulz, S. Siegert, Neuroscience Letters 707 (2019).
[Published Version]
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| Files available
| DOI
| WoS
| PubMed | Europe PMC
M.E. Maes, G. Colombo, R. Schulz, S. Siegert, Neuroscience Letters 707 (2019).
2017 | Published | Journal Article | IST-REx-ID: 557 |

AAV2 mediated transduction of the mouse retina after optic nerve injury
R. Nickells, H. Schmitt, M.E. Maes, C. Schlamp, Investigative Ophthalmology and Visual Science 58 (2017) 6091–6104.
[Published Version]
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| DOI
R. Nickells, H. Schmitt, M.E. Maes, C. Schlamp, Investigative Ophthalmology and Visual Science 58 (2017) 6091–6104.
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12 Publications
2025 | Published | Journal Article | IST-REx-ID: 19566 |

Optic nerve crush does not induce retinal ganglion cell loss in the contralateral eye
Schoot Uiterkamp, Florianne E, Optic nerve crush does not induce retinal ganglion cell loss in the contralateral eye. Investigative Ophthalmology & Visual Science 66 (3). 2025
[Published Version]
View
| Files available
| DOI
Schoot Uiterkamp, Florianne E, Optic nerve crush does not induce retinal ganglion cell loss in the contralateral eye. Investigative Ophthalmology & Visual Science 66 (3). 2025
2023 | Published | Journal Article | IST-REx-ID: 14363 |

Mitochondrial network adaptations of microglia reveal sex-specific stress response after injury and UCP2 knockout
M.E. Maes, G. Colombo, F.E. Schoot Uiterkamp, F. Sternberg, A. Venturino, E.E. Pohl, S. Siegert, IScience 26 (2023).
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
M.E. Maes, G. Colombo, F.E. Schoot Uiterkamp, F. Sternberg, A. Venturino, E.E. Pohl, S. Siegert, IScience 26 (2023).
2023 | Published | Journal Article | IST-REx-ID: 14401 |

BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps
M.E. Maes, R.J. Donahue, C.L. Schlamp, O.J. Marola, R.T. Libby, R.W. Nickells, Molecular Neurodegeneration 18 (2023).
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
M.E. Maes, R.J. Donahue, C.L. Schlamp, O.J. Marola, R.T. Libby, R.W. Nickells, Molecular Neurodegeneration 18 (2023).
2021 | Published | Journal Article | IST-REx-ID: 10000 |

Increased susceptibility and intrinsic apoptotic signaling in neurons by induced HDAC3 expression
H.M. Schmitt, R.L. Fehrman, M.E. Maes, H. Yang, L.W. Guo, C.L. Schlamp, H.R. Pelzel, R.W. Nickells, Investigative Ophthalmology and Visual Science 62 (2021).
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
H.M. Schmitt, R.L. Fehrman, M.E. Maes, H. Yang, L.W. Guo, C.L. Schlamp, H.R. Pelzel, R.W. Nickells, Investigative Ophthalmology and Visual Science 62 (2021).
2021 | Published | Journal Article | IST-REx-ID: 9761 |

The influence of mitochondrial dynamics and function on retinal ganglion cell susceptibility in optic nerve disease
N.A. Muench, S. Patel, M.E. Maes, R.J. Donahue, A. Ikeda, R.W. Nickells, Cells 10 (2021).
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
N.A. Muench, S. Patel, M.E. Maes, R.J. Donahue, A. Ikeda, R.W. Nickells, Cells 10 (2021).
2021 | Published | Journal Article | IST-REx-ID: 9009 |

Characteristics of intracellular propagation of mitochondrial BAX recruitment during apoptosis
J.A. Grosser, M.E. Maes, R.W. Nickells, Apoptosis 26 (2021) 132–145.
[Submitted Version]
View
| DOI
| Download Submitted Version (ext.)
| WoS
| PubMed | Europe PMC
J.A. Grosser, M.E. Maes, R.W. Nickells, Apoptosis 26 (2021) 132–145.
2021 | Published | Journal Article | IST-REx-ID: 9642 |

Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain
A. Venturino, R. Schulz, H. De Jesús-Cortés, M.E. Maes, B. Nagy, F. Reilly-Andújar, G. Colombo, R.J. Cubero, F.E. Schoot Uiterkamp, M.F. Bear, S. Siegert, Cell Reports 36 (2021).
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
A. Venturino, R. Schulz, H. De Jesús-Cortés, M.E. Maes, B. Nagy, F. Reilly-Andújar, G. Colombo, R.J. Cubero, F.E. Schoot Uiterkamp, M.F. Bear, S. Siegert, Cell Reports 36 (2021).
2021 | Published | Journal Article | IST-REx-ID: 10655 |

Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment
M.E. Maes, G.M. Wögenstein, G. Colombo, R. Casado Polanco, S. Siegert, Molecular Therapy - Methods and Clinical Development 23 (2021) 210–224.
[Published Version]
View
| Files available
| DOI
| WoS
M.E. Maes, G.M. Wögenstein, G. Colombo, R. Casado Polanco, S. Siegert, Molecular Therapy - Methods and Clinical Development 23 (2021) 210–224.
2020 | Published | Journal Article | IST-REx-ID: 7033 |

BAX-depleted retinal ganglion cells survive and become quiescent following optic nerve damage
R. Donahue, M.E. Maes, J. Grosser, R. Nickells, Molecular Neurobiology 57 (2020) 1070–1084.
[Submitted Version]
View
| DOI
| Download Submitted Version (ext.)
| WoS
| PubMed | Europe PMC
R. Donahue, M.E. Maes, J. Grosser, R. Nickells, Molecular Neurobiology 57 (2020) 1070–1084.
2019 | Published | Journal Article | IST-REx-ID: 7095 |

Completion of BAX recruitment correlates with mitochondrial fission during apoptosis
M.E. Maes, J.A. Grosser, R.L. Fehrman, C.L. Schlamp, R.W. Nickells, Scientific Reports 9 (2019).
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
M.E. Maes, J.A. Grosser, R.L. Fehrman, C.L. Schlamp, R.W. Nickells, Scientific Reports 9 (2019).
2019 | Published | Journal Article | IST-REx-ID: 6521 |

Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges
M.E. Maes, G. Colombo, R. Schulz, S. Siegert, Neuroscience Letters 707 (2019).
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
M.E. Maes, G. Colombo, R. Schulz, S. Siegert, Neuroscience Letters 707 (2019).
2017 | Published | Journal Article | IST-REx-ID: 557 |

AAV2 mediated transduction of the mouse retina after optic nerve injury
R. Nickells, H. Schmitt, M.E. Maes, C. Schlamp, Investigative Ophthalmology and Visual Science 58 (2017) 6091–6104.
[Published Version]
View
| Files available
| DOI
R. Nickells, H. Schmitt, M.E. Maes, C. Schlamp, Investigative Ophthalmology and Visual Science 58 (2017) 6091–6104.