Nuclear pore complex maintenance and implications for age-related diseases

Liu J, Hetzer M. 2022. Nuclear pore complex maintenance and implications for age-related diseases. Trends in Cell Biology. 32(3), P216-227.

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Journal Article | Published | English

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Author
Liu, Jinqiang; Hetzer, MartinISTA

Corresponding author has ISTA affiliation

Abstract
Nuclear pore complexes (NPCs) bridge the nucleus and the cytoplasm and are indispensable for crucial cellular activities, such as bidirectional molecular trafficking and gene transcription regulation. The discovery of long-lived proteins (LLPs) in NPCs from postmitotic cells raises the exciting possibility that the maintenance of NPC integrity might play an inherent role in lifelong cell function. Age-dependent deterioration of NPCs and loss of nuclear integrity have been linked to age-related decline in postmitotic cell function and degenerative diseases. In this review, we discuss our current understanding of NPC maintenance in proliferating and postmitotic cells, and how malfunction of nucleoporins (Nups) might contribute to the pathogenesis of various neurodegenerative and cardiovascular diseases.
Keywords
Publishing Year
Date Published
2022-03-01
Journal Title
Trends in Cell Biology
Publisher
Elsevier
Volume
32
Issue
3
Page
P216-227
ISSN
IST-REx-ID

Cite this

Liu J, Hetzer M. Nuclear pore complex maintenance and implications for age-related diseases. Trends in Cell Biology. 2022;32(3):P216-227. doi:10.1016/j.tcb.2021.10.001
Liu, J., & Hetzer, M. (2022). Nuclear pore complex maintenance and implications for age-related diseases. Trends in Cell Biology. Elsevier. https://doi.org/10.1016/j.tcb.2021.10.001
Liu, Jinqiang, and Martin Hetzer. “Nuclear Pore Complex Maintenance and Implications for Age-Related Diseases.” Trends in Cell Biology. Elsevier, 2022. https://doi.org/10.1016/j.tcb.2021.10.001.
J. Liu and M. Hetzer, “Nuclear pore complex maintenance and implications for age-related diseases,” Trends in Cell Biology, vol. 32, no. 3. Elsevier, pp. P216-227, 2022.
Liu J, Hetzer M. 2022. Nuclear pore complex maintenance and implications for age-related diseases. Trends in Cell Biology. 32(3), P216-227.
Liu, Jinqiang, and Martin Hetzer. “Nuclear Pore Complex Maintenance and Implications for Age-Related Diseases.” Trends in Cell Biology, vol. 32, no. 3, Elsevier, 2022, pp. P216-227, doi:10.1016/j.tcb.2021.10.001.

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