A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces

Meisenbichler C, Kluibenschedl F, Müller T. 2020. A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces. Analytical Chemistry. 92(21), 14314–14318.

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Journal Article | Published | English

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Author
Meisenbichler, Christina; Kluibenschedl, FlorianISTA; Müller, Thomas
Abstract
Desorption electrospray ionization (DESI), easy ambient sonic-spray ionization (EASI) and low-temperature plasma (LTP) ionization are powerful ambient ionization techniques for mass spectrometry. However, every single method has its limitation in terms of polarity and molecular weight of analyte molecules. After the miniaturization of every possible component of the different ion sources, we finally were able to embed two emitters and an ion transfer tubing into a small, hand-held device. The pen-like interface is connected to the mass spectrometer and a separate control unit via a bundle of flexible tubing and cables. The novel device allows the user to ionize an extended range of chemicals by simple switching between DESI, voltage-free EASI, or LTP ionization as well as to freely move the interface over a surface of interest. A mini camera, which is mounted on the tip of the pen, magnifies the desorption area and enables a simple positioning of the pen. The interface was successfully tested using different types of chemicals, pharmaceuticals, and real life samples. Moreover, the combination of optical data from the camera module and chemical data obtained by mass analysis facilitates a novel type of imaging mass spectrometry, which we name “interactive mass spectrometry imaging (IMSI)”.
Publishing Year
Date Published
2020-10-16
Journal Title
Analytical Chemistry
Volume
92
Issue
21
Page
14314-14318
IST-REx-ID

Cite this

Meisenbichler C, Kluibenschedl F, Müller T. A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces. Analytical Chemistry. 2020;92(21):14314-14318. doi:10.1021/acs.analchem.0c02615
Meisenbichler, C., Kluibenschedl, F., & Müller, T. (2020). A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces. Analytical Chemistry. American Chemical Society. https://doi.org/10.1021/acs.analchem.0c02615
Meisenbichler, Christina, Florian Kluibenschedl, and Thomas Müller. “A 3-in-1 Hand-Held Ambient Mass Spectrometry Interface for Identification and 2D Localization of Chemicals on Surfaces.” Analytical Chemistry. American Chemical Society, 2020. https://doi.org/10.1021/acs.analchem.0c02615.
C. Meisenbichler, F. Kluibenschedl, and T. Müller, “A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces,” Analytical Chemistry, vol. 92, no. 21. American Chemical Society, pp. 14314–14318, 2020.
Meisenbichler C, Kluibenschedl F, Müller T. 2020. A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces. Analytical Chemistry. 92(21), 14314–14318.
Meisenbichler, Christina, et al. “A 3-in-1 Hand-Held Ambient Mass Spectrometry Interface for Identification and 2D Localization of Chemicals on Surfaces.” Analytical Chemistry, vol. 92, no. 21, American Chemical Society, 2020, pp. 14314–18, doi:10.1021/acs.analchem.0c02615.
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