Spinal cords: Symphonies of interneurons across species

Wilson AC, Sweeney LB. 2023. Spinal cords: Symphonies of interneurons across species. Frontiers in Neural Circuits. 17, 1146449.

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Journal Article | Published | English

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Abstract
Vertebrate movement is orchestrated by spinal inter- and motor neurons that, together with sensory and cognitive input, produce dynamic motor behaviors. These behaviors vary from the simple undulatory swimming of fish and larval aquatic species to the highly coordinated running, reaching and grasping of mice, humans and other mammals. This variation raises the fundamental question of how spinal circuits have changed in register with motor behavior. In simple, undulatory fish, exemplified by the lamprey, two broad classes of interneurons shape motor neuron output: ipsilateral-projecting excitatory neurons, and commissural-projecting inhibitory neurons. An additional class of ipsilateral inhibitory neurons is required to generate escape swim behavior in larval zebrafish and tadpoles. In limbed vertebrates, a more complex spinal neuron composition is observed. In this review, we provide evidence that movement elaboration correlates with an increase and specialization of these three basic interneuron types into molecularly, anatomically, and functionally distinct subpopulations. We summarize recent work linking neuron types to movement-pattern generation across fish, amphibians, reptiles, birds and mammals.
Publishing Year
Date Published
2023-04-26
Journal Title
Frontiers in Neural Circuits
Acknowledgement
This work was supported by the ERC Starting grant, ERC-2021-STG #101041551.
Volume
17
Article Number
1146449
ISSN
IST-REx-ID

Cite this

Wilson AC, Sweeney LB. Spinal cords: Symphonies of interneurons across species. Frontiers in Neural Circuits. 2023;17. doi:10.3389/fncir.2023.1146449
Wilson, A. C., & Sweeney, L. B. (2023). Spinal cords: Symphonies of interneurons across species. Frontiers in Neural Circuits. Frontiers. https://doi.org/10.3389/fncir.2023.1146449
Wilson, Alexia C, and Lora B. Sweeney. “Spinal Cords: Symphonies of Interneurons across Species.” Frontiers in Neural Circuits. Frontiers, 2023. https://doi.org/10.3389/fncir.2023.1146449.
A. C. Wilson and L. B. Sweeney, “Spinal cords: Symphonies of interneurons across species,” Frontiers in Neural Circuits, vol. 17. Frontiers, 2023.
Wilson AC, Sweeney LB. 2023. Spinal cords: Symphonies of interneurons across species. Frontiers in Neural Circuits. 17, 1146449.
Wilson, Alexia C., and Lora B. Sweeney. “Spinal Cords: Symphonies of Interneurons across Species.” Frontiers in Neural Circuits, vol. 17, 1146449, Frontiers, 2023, doi:10.3389/fncir.2023.1146449.
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2024-01-03
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