Central amygdala circuits modulate food consumption through a positive-valence mechanism
Douglass AM, Kucukdereli H, Ponserre M, Markovic M, Gründemann J, Strobel C, Alcala Morales PL, Conzelmann K-K, Lüthi A, Klein R. 2017. Central amygdala circuits modulate food consumption through a positive-valence mechanism. Nature Neuroscience. 20(10), 1384–1394.
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| English
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Author
Douglass, Amelia M.ISTA
;
Kucukdereli, Hakan;
Ponserre, Marion;
Markovic, Milica;
Gründemann, Jan;
Strobel, Cornelia;
Alcala Morales, Pilar L;
Conzelmann, Karl-Klaus;
Lüthi, Andreas;
Klein, Rüdiger

Abstract
The complex behaviors underlying reward seeking and consumption are integral to organism survival. The hypothalamus and mesolimbic dopamine system are key mediators of these behaviors, yet regulation of appetitive and consummatory behaviors outside of these regions is poorly understood. The central nucleus of the amygdala (CeA) has been implicated in feeding and reward, but the neurons and circuit mechanisms that positively regulate these behaviors remain unclear. Here, we defined the neuronal mechanisms by which CeA neurons promote food consumption. Using in vivo activity manipulations and Ca2+ imaging in mice, we found that GABAergic serotonin receptor 2a (Htr2a)-expressing CeA neurons modulate food consumption, promote positive reinforcement and are active in vivo during eating. We demonstrated electrophysiologically, anatomically and behaviorally that intra-CeA and long-range circuit mechanisms underlie these behaviors. Finally, we showed that CeAHtr2a neurons receive inputs from feeding-relevant brain regions. Our results illustrate how defined CeA neural circuits positively regulate food consumption.
Publishing Year
Date Published
2017-10-01
Journal Title
Nature Neuroscience
Publisher
Springer Nature
Volume
20
Issue
10
Page
1384-1394
ISSN
eISSN
IST-REx-ID
Cite this
Douglass AM, Kucukdereli H, Ponserre M, et al. Central amygdala circuits modulate food consumption through a positive-valence mechanism. Nature Neuroscience. 2017;20(10):1384-1394. doi:10.1038/nn.4623
Douglass, A. M., Kucukdereli, H., Ponserre, M., Markovic, M., Gründemann, J., Strobel, C., … Klein, R. (2017). Central amygdala circuits modulate food consumption through a positive-valence mechanism. Nature Neuroscience. Springer Nature. https://doi.org/10.1038/nn.4623
Douglass, Amelia M., Hakan Kucukdereli, Marion Ponserre, Milica Markovic, Jan Gründemann, Cornelia Strobel, Pilar L Alcala Morales, Karl-Klaus Conzelmann, Andreas Lüthi, and Rüdiger Klein. “Central Amygdala Circuits Modulate Food Consumption through a Positive-Valence Mechanism.” Nature Neuroscience. Springer Nature, 2017. https://doi.org/10.1038/nn.4623.
A. M. Douglass et al., “Central amygdala circuits modulate food consumption through a positive-valence mechanism,” Nature Neuroscience, vol. 20, no. 10. Springer Nature, pp. 1384–1394, 2017.
Douglass AM, Kucukdereli H, Ponserre M, Markovic M, Gründemann J, Strobel C, Alcala Morales PL, Conzelmann K-K, Lüthi A, Klein R. 2017. Central amygdala circuits modulate food consumption through a positive-valence mechanism. Nature Neuroscience. 20(10), 1384–1394.
Douglass, Amelia M., et al. “Central Amygdala Circuits Modulate Food Consumption through a Positive-Valence Mechanism.” Nature Neuroscience, vol. 20, no. 10, Springer Nature, 2017, pp. 1384–94, doi:10.1038/nn.4623.
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