Role of cAMP in TIR1/AFB auxin signaling: Open issues

Friml, Jiří

Role of cAMP in TIR1/AFB auxin signaling: Open issues

Friml J. 2026. Role of cAMP in TIR1/AFB auxin signaling: Open issues. Trends in Plant Science. 31(2), 136–138.

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2026_TrendsPlantScience_Friml.pdf 432.79 KB [Published Version]

DOI

10.1016/j.tplants.2025.10.018

Journal Article | Published | English

Scopus indexed

Author

Friml, Jirí^ISTA

Corresponding author has ISTA affiliation

Department

Friml Group

Grant

Cyclic nucleotides as second messengers in plants
Guanylate cyclase activity of TIR1/AFBs auxin receptors

Abstract

The canonical mechanism by which the phytohormone auxin regulates transcription has been one of the cornerstones of plant signaling. The recent unexpected discovery of cyclic AMP (cAMP) as a second messenger in this pathway has revised its foundations while leaving many open questions and gaps in our understanding; these will be discussed in this forum article.

Publishing Year

2026

Date Published

2026-02-01

Journal Title

Trends in Plant Science

Publisher

Elsevier

Acknowledgement

I apologize to colleagues whose relevant work I was unable to cite due to space limitations. This work was funded by the European Union (ERC, CYNIPS, 101142681) and Austrian Science Fund (FWF; 37051-B). I thank Drs Huihuang Chen, Yuanrong Pei, Jason Reed, Linlin Qi, and Dolf Weijers for inspiration and critical input.

Volume

Issue

Page

136-138

ISSN

1360-1385

eISSN

1878-4372

IST-REx-ID

20725

Cite this

Friml J. Role of cAMP in TIR1/AFB auxin signaling: Open issues. Trends in Plant Science. 2026;31(2):136-138. doi:10.1016/j.tplants.2025.10.018

Friml, J. (2026). Role of cAMP in TIR1/AFB auxin signaling: Open issues. Trends in Plant Science. Elsevier. https://doi.org/10.1016/j.tplants.2025.10.018

Friml, Jiří. “Role of CAMP in TIR1/AFB Auxin Signaling: Open Issues.” Trends in Plant Science. Elsevier, 2026. https://doi.org/10.1016/j.tplants.2025.10.018.

J. Friml, “Role of cAMP in TIR1/AFB auxin signaling: Open issues,” Trends in Plant Science, vol. 31, no. 2. Elsevier, pp. 136–138, 2026.

Friml J. 2026. Role of cAMP in TIR1/AFB auxin signaling: Open issues. Trends in Plant Science. 31(2), 136–138.

Friml, Jiří. “Role of CAMP in TIR1/AFB Auxin Signaling: Open Issues.” Trends in Plant Science, vol. 31, no. 2, Elsevier, 2026, pp. 136–38, doi:10.1016/j.tplants.2025.10.018.

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