Efficient optimization and synthesis of diverse azaarenes via nitrogen atom insertion under continuous flow conditions
Moon S, Reisenbauer J, Paschke A-SK, Scotto A, Terraneo L, Brenner N, Lefebvre Q, Fessard TC, Morandi B. 2025. Efficient optimization and synthesis of diverse azaarenes via nitrogen atom insertion under continuous flow conditions. Chemical Communications. 61(87), 16993–16996.
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Author
Moon, Sooyeon;
Reisenbauer, Julia C.ISTA;
Paschke, Ann-Sophie K.;
Scotto, Alessandro;
Terraneo, Luca;
Brenner, Niklas;
Lefebvre, Quentin;
Fessard, Thomas C.;
Morandi, Bill
Abstract
We report the development of a continuous flow approach to nitrogen atom insertion. The setup is modular, enabling the rapid optimization of reaction conditions for a wide range of substrates. The milder reaction conditions led to an improved substrate scope and functional group tolerance compared to batch conditions. The reactions can also be safely scaled up to preparative scale.
Publishing Year
Date Published
2025-10-06
Journal Title
Chemical Communications
Publisher
Royal Society of Chemistry
Volume
61
Issue
87
Page
16993-16996
ISSN
eISSN
IST-REx-ID
Cite this
Moon S, Reisenbauer J, Paschke A-SK, et al. Efficient optimization and synthesis of diverse azaarenes via nitrogen atom insertion under continuous flow conditions. Chemical Communications. 2025;61(87):16993-16996. doi:10.1039/d5cc03194j
Moon, S., Reisenbauer, J., Paschke, A.-S. K., Scotto, A., Terraneo, L., Brenner, N., … Morandi, B. (2025). Efficient optimization and synthesis of diverse azaarenes via nitrogen atom insertion under continuous flow conditions. Chemical Communications. Royal Society of Chemistry. https://doi.org/10.1039/d5cc03194j
Moon, Sooyeon, Julia Reisenbauer, Ann-Sophie K. Paschke, Alessandro Scotto, Luca Terraneo, Niklas Brenner, Quentin Lefebvre, Thomas C. Fessard, and Bill Morandi. “Efficient Optimization and Synthesis of Diverse Azaarenes via Nitrogen Atom Insertion under Continuous Flow Conditions.” Chemical Communications. Royal Society of Chemistry, 2025. https://doi.org/10.1039/d5cc03194j.
S. Moon et al., “Efficient optimization and synthesis of diverse azaarenes via nitrogen atom insertion under continuous flow conditions,” Chemical Communications, vol. 61, no. 87. Royal Society of Chemistry, pp. 16993–16996, 2025.
Moon S, Reisenbauer J, Paschke A-SK, Scotto A, Terraneo L, Brenner N, Lefebvre Q, Fessard TC, Morandi B. 2025. Efficient optimization and synthesis of diverse azaarenes via nitrogen atom insertion under continuous flow conditions. Chemical Communications. 61(87), 16993–16996.
Moon, Sooyeon, et al. “Efficient Optimization and Synthesis of Diverse Azaarenes via Nitrogen Atom Insertion under Continuous Flow Conditions.” Chemical Communications, vol. 61, no. 87, Royal Society of Chemistry, 2025, pp. 16993–96, doi:10.1039/d5cc03194j.
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