Facile access to N-substituted pyridyl ligands
Petrik A, Bena A, Baunis H, Kelch RM, Yoon TP, Pieber B. 2026. Facile access to N-substituted pyridyl ligands. Advanced Synthesis & Catalysis. 368(9), e70417.
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Author
Petrik, AdamISTA;
Bena, AleksanderISTA;
Baunis, HaraldsISTA;
Kelch, Riley M.;
Yoon, Tehshik P.;
Pieber, BartholomäusISTA 
Corresponding author has ISTA affiliation
Department
Abstract
Pyridyl motifs equipped with N-substituents can be powerful ligands for catalysis, yet their broader adoption is limited by the lack of a practical method to prepare these scaffolds. We report a modular, robust, and versatile Buchwald–Hartwig amination protocol that enables the rapid synthesis of bipyridine, phenanthroline, terpyridine, and pybox ligands bearing dialkylamine, diarylamine, and heteroaromatic N-substituents. These conditions streamline ligand library synthesis and will facilitate systematic studies in catalysis and related applications.
Publishing Year
Date Published
2026-05-05
Journal Title
Advanced Synthesis & Catalysis
Publisher
Wiley
Acknowledgement
We gratefully acknowledge ISTA for generous financial support. B.P. acknowledges the Austrian Science Fund (PAT 1250924) and the ACS GCI Pharmaceutical Roundtable for funding; T.P.Y acknowledges the NSF(CHE-2349003) for financial support. This research was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Lab Support Facility, Mass Spec Facility, NMR facility, and the Miba Machine Shop. We specifically thank Aikaterina Paraskevopoulou for HRMS measurements and Jan Pecak for support with ICP-OES experi-ments. NMR facilities at UW−Madison were supported by the NSF(CHE-1048642) and a generous gift from Paul J. and Margaret M. Bender. Open Access funding provided by Institute of Science and Technology Austria/KEMÖ. This study was supported by Austrian Science Fund (PAT 1250924), ACSGCI Pharmaceutical Roundtable, and National Science Foundation(CHE-2349003) and (CHE-1048642).
Acknowledged SSUs
Volume
368
Issue
9
Article Number
e70417
ISSN
eISSN
IST-REx-ID
Cite this
Petrik A, Bena A, Baunis H, Kelch RM, Yoon TP, Pieber B. Facile access to N-substituted pyridyl ligands. Advanced Synthesis & Catalysis. 2026;368(9). doi:10.1002/adsc.70417
Petrik, A., Bena, A., Baunis, H., Kelch, R. M., Yoon, T. P., & Pieber, B. (2026). Facile access to N-substituted pyridyl ligands. Advanced Synthesis & Catalysis. Wiley. https://doi.org/10.1002/adsc.70417
Petrik, Adam, Aleksander Bena, Haralds Baunis, Riley M. Kelch, Tehshik P. Yoon, and Bartholomäus Pieber. “Facile Access to N-Substituted Pyridyl Ligands.” Advanced Synthesis & Catalysis. Wiley, 2026. https://doi.org/10.1002/adsc.70417.
A. Petrik, A. Bena, H. Baunis, R. M. Kelch, T. P. Yoon, and B. Pieber, “Facile access to N-substituted pyridyl ligands,” Advanced Synthesis & Catalysis, vol. 368, no. 9. Wiley, 2026.
Petrik A, Bena A, Baunis H, Kelch RM, Yoon TP, Pieber B. 2026. Facile access to N-substituted pyridyl ligands. Advanced Synthesis & Catalysis. 368(9), e70417.
Petrik, Adam, et al. “Facile Access to N-Substituted Pyridyl Ligands.” Advanced Synthesis & Catalysis, vol. 368, no. 9, e70417, Wiley, 2026, doi:10.1002/adsc.70417.
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