A family of metabotropic glutamate receptors
Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. 1992. A family of metabotropic glutamate receptors. Neuron. 8(1), 169–179.
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Journal Article
| Published
| English
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Author
Tanabe, Yasuto;
Masu, Masayuki;
Ishii, Takahiro;
Shigemoto, RyuichiISTA 
;
Nakanishi, Shigetada
;
Nakanishi, ShigetadaAbstract
Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA- transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns.
Publishing Year
Date Published
1992-01-01
Journal Title
Neuron
Acknowledgement
We are grateful to Noboru Mizuno for helpful discussion and Akira Uesugi for photographic assistance. This work was sup. ported in part by research grants from the Ministry of Education, Science and Culture of Japan. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC Sec-tion 1734 solely to indicate this fact.
Volume
8
Issue
1
Page
169 - 179
ISSN
IST-REx-ID
Cite this
Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. A family of metabotropic glutamate receptors. Neuron. 1992;8(1):169-179. doi:10.1016/0896-6273(92)90118-W
Tanabe, Y., Masu, M., Ishii, T., Shigemoto, R., & Nakanishi, S. (1992). A family of metabotropic glutamate receptors. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(92)90118-W
Tanabe, Yasuto, Masayuki Masu, Takahiro Ishii, Ryuichi Shigemoto, and Shigetada Nakanishi. “A Family of Metabotropic Glutamate Receptors.” Neuron. Elsevier, 1992. https://doi.org/10.1016/0896-6273(92)90118-W.
Y. Tanabe, M. Masu, T. Ishii, R. Shigemoto, and S. Nakanishi, “A family of metabotropic glutamate receptors,” Neuron, vol. 8, no. 1. Elsevier, pp. 169–179, 1992.
Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. 1992. A family of metabotropic glutamate receptors. Neuron. 8(1), 169–179.
Tanabe, Yasuto, et al. “A Family of Metabotropic Glutamate Receptors.” Neuron, vol. 8, no. 1, Elsevier, 1992, pp. 169–79, doi:10.1016/0896-6273(92)90118-W.
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