Metabolism of glutamate and ammonia in astrocyte an immunocytochemical study
Kaneko T, Shigemoto R, Mizuno N. 1988. Metabolism of glutamate and ammonia in astrocyte an immunocytochemical study. Brain Research. 457(1), 160–164.
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Author
Kaneko, Takeshi;
Shigemoto, RyuichiISTA 
;
Mizuno, Noboru
;
Mizuno, NoboruAbstract
Alpha-ketoglutamate (α-KG) reductive amination activity in rat brain was found to be mostly absorbed with an antibody against liver glutamate dehydrogenase. With this and anti-glutamine synthetase antibodies, α-KG reductive amination activity was immunocytochemically shown to coexist with glutamine synthetase activity in astrocytes. The results suggest that astrocytes de novo synthesize glutamate from α-KG and ammonia, and metabolize it to glutamine.
Publishing Year
Date Published
1988-08-02
Journal Title
Brain Research
Acknowledgement
The authors are grateful to Akira Uesugi and Ken’ichi Uesugi for photographic help. This work was supported by the Niwa Medical Research Foundation and Grants-in-Aid for Special -Project Research (62121004), for General Scientific Research (62480098) and for Encouragement of Young Scientists (63770043) from the Ministry of Education, Science and Culture of Japan.
Volume
457
Issue
1
Page
160 - 164
ISSN
eISSN
IST-REx-ID
Cite this
Kaneko T, Shigemoto R, Mizuno N. Metabolism of glutamate and ammonia in astrocyte an immunocytochemical study. Brain Research. 1988;457(1):160-164. doi:10.1016/0006-8993(88)90069-8
Kaneko, T., Shigemoto, R., & Mizuno, N. (1988). Metabolism of glutamate and ammonia in astrocyte an immunocytochemical study. Brain Research. Elsevier. https://doi.org/10.1016/0006-8993(88)90069-8
Kaneko, Takeshi, Ryuichi Shigemoto, and Noboru Mizuno. “Metabolism of Glutamate and Ammonia in Astrocyte an Immunocytochemical Study.” Brain Research. Elsevier, 1988. https://doi.org/10.1016/0006-8993(88)90069-8.
T. Kaneko, R. Shigemoto, and N. Mizuno, “Metabolism of glutamate and ammonia in astrocyte an immunocytochemical study,” Brain Research, vol. 457, no. 1. Elsevier, pp. 160–164, 1988.
Kaneko T, Shigemoto R, Mizuno N. 1988. Metabolism of glutamate and ammonia in astrocyte an immunocytochemical study. Brain Research. 457(1), 160–164.
Kaneko, Takeshi, et al. “Metabolism of Glutamate and Ammonia in Astrocyte an Immunocytochemical Study.” Brain Research, vol. 457, no. 1, Elsevier, 1988, pp. 160–64, doi:10.1016/0006-8993(88)90069-8.
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