Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb
Hayashi Y, Momiyama A, Takahashi T, Ohishi H, Ogawa Meguro R, Shigemoto R, Mizuno N, Nakanishi S. 1993. Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Nature. 366(6456), 687–690.
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Journal Article
| Published
| English
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Author
Hayashi, Yasunori;
Momiyama, Akiko;
Takahashi, Tomoyuki;
Ohishi, Hitoshi;
Ogawa Meguro, Reiko;
Shigemoto, RyuichiISTA 
;
Mizuno, Noboru;
Nakanishi, Shigetada
;
Mizuno, Noboru;
Nakanishi, ShigetadaAbstract
VARIOUS functions of glutamate transmission are mediated by both ionotropic and metabotropic glutamate receptors1. The metabotropic glutamate receptors (mGluRs) consist of at least six different subtypes that are classified into three subgroups, mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6 (refs 1-5), but their physiological roles are largely unknown. Here we report the identification of a very potent agonist for mGluR2/mGluR3, DCG-IV, and the specific localization of mGluR2 in granule cell dendrites that form dendrodendritic synapses with mitral cells in the accessory olfactory bulb. Using the DCG-IV agonist for mGluR2 in combination with slice patchrecording, we demonstrate that the granule cell mGluR2 presynaptically suppresses inhibitory GABA (γ-aminobutyrate) transmission to the mitral cell. Our results indicate that mGluR2 in granule cells plays an important role in the persistent excitation of olfactory sensory transmission in the accessory olfactory bulb by relieving mitral cells from the GABA inhibition.
Publishing Year
Date Published
1993-01-01
Journal Title
Nature
Publisher
Nature Publishing Group
Acknowledgement
We thank Y. Ohfune and K. Shimamoto for DCG-IV, M. Kuno for advice and A. Uesugi for photographic assistance. Partly supported by research grants from the Ministry of Education, Science and Culture of Japan, the Ministry of Health and Welfare of Japan and the Senri Life Science Foundation.
Volume
366
Issue
6456
Page
687 - 690
ISSN
IST-REx-ID
Cite this
Hayashi Y, Momiyama A, Takahashi T, et al. Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Nature. 1993;366(6456):687-690. doi:10.1038/366687a0
Hayashi, Y., Momiyama, A., Takahashi, T., Ohishi, H., Ogawa Meguro, R., Shigemoto, R., … Nakanishi, S. (1993). Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Nature. Nature Publishing Group. https://doi.org/10.1038/366687a0
Hayashi, Yasunori, Akiko Momiyama, Tomoyuki Takahashi, Hitoshi Ohishi, Reiko Ogawa Meguro, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Role of a Metabotropic Glutamate Receptor in Synaptic Modulation in the Accessory Olfactory Bulb.” Nature. Nature Publishing Group, 1993. https://doi.org/10.1038/366687a0.
Y. Hayashi et al., “Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb,” Nature, vol. 366, no. 6456. Nature Publishing Group, pp. 687–690, 1993.
Hayashi Y, Momiyama A, Takahashi T, Ohishi H, Ogawa Meguro R, Shigemoto R, Mizuno N, Nakanishi S. 1993. Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Nature. 366(6456), 687–690.
Hayashi, Yasunori, et al. “Role of a Metabotropic Glutamate Receptor in Synaptic Modulation in the Accessory Olfactory Bulb.” Nature, vol. 366, no. 6456, Nature Publishing Group, 1993, pp. 687–90, doi:10.1038/366687a0.
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